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← Childhood Cancer Genomics (PDQ®)

HEALTH PROFESSIONAL · SOURCE READING

Angiocentric gliomas

Source: Childhood Cancer Genomics (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: April 30, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.

Context: Central Nervous System Tumors / Astrocytomas, Other Gliomas, and Glioneuronal/Neuronal Tumors / Molecular features and recurrent genomic alterations

Angiocentric gliomas typically arise in children and young adults as cerebral tumors presenting with seizures.[24]

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Two reports in 2016 identified MYB gene alterations as being present in almost all cases diagnosed as angiocentric glioma, with QKI being the primary fusion partner in cases where fusion-partner testing was possible.[4,25] While angiocentric gliomas most commonly occur supratentorially, brain stem angiocentric gliomas with MYB::QKI fusions have also been reported.[26,27]

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Preserved source evidence · Independent clinical review pending · Not medical advice