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Supratentorial ependymomas with YAP1 fusions (ST-EPN-YAP1)
Source: Childhood Cancer Genomics (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: April 30, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.
ST-EPN-YAP1 is the second, less common subset of supratentorial ependymomas and has fusions involving YAP1 on chromosome 11. ST-EPN-YAP1 is characterized by the following:
Median age at diagnosis of 1.4 years.[166]
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Presence of a gene fusion involving YAP1, with MAMLD1 being the most common fusion partner.[166,181]
A relatively stable genome with few chromosomal changes other than the YAP1 fusion.[166]
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Preserved source evidence · Independent clinical review pending · Not medical advice