TriangleHEALTH PROFESSIONAL · SOURCE READING
Lung cancer
Source: Late Effects of Treatment for Childhood Cancer (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: April 14, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.
Context: Subsequent Neoplasms / Therapy-Related Solid SNs
Among childhood cancer survivor cohorts, lung cancer represents a relatively uncommon SN. A PENTEC systematic review reported a median latency period of 25 years (range, 19–29 years) between the childhood cancer diagnosis and the development of a lung SN.[61] The ERR/Gy was 0.068, compared with background cumulative risks. After 20 Gy, the excess absolute risk was predicted to be 0.27% at 50 years. After 50 Gy, the excess absolute risk was predicted to be 0.7% at 50 years.[61]
Evidence (excess risk of lung cancer):
The 30-year cumulative incidence of lung cancer among CCSS participants was 0.16% (95% CI, 0.09%–0.23%), representing a SIR of 4.0 (95% CI, 2.9–5.4).[88]
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The 30-year cumulative incidence of lung cancer among CCSS participants was 0.16% (95% CI, 0.09%–0.23%), representing a SIR of 4.0 (95% CI, 2.9–5.4).[88]
Lung cancer risk demonstrated a dose-related association with chest radiation dose: 10 to 30 Gy (HR, 3.4; 95% CI, 1.05–11.0), more than 30 to 40 Gy (HR, 4.6; 95% CI, 1.5–14.3), and more than 40 Gy (HR, 9.1; 95% CI, 3.1–27.0).
The 30-year cumulative incidence of lung cancer among CCSS participants was 0.16% (95% CI, 0.09%–0.23%), representing a SIR of 4.0 (95% CI, 2.9–5.4).[88]
Cumulative incidence of lung SMNs was higher among current or past smokers, compared with those who had never smoked.
The 30-year cumulative incidence of lung cancer among CCSS participants was 0.16% (95% CI, 0.09%–0.23%), representing a SIR of 4.0 (95% CI, 2.9–5.4).[88]
The SIR for lung cancer was highest among survivors of Hodgkin lymphoma (SIR, 9.3; 95% CI, 6.2–13.4) and bone cancer (SIR, 4.4; 95% CI, 1.8–9.1).
The 25-year cumulative incidence of lung cancer among the DCOG-LATER cohort was 0.1% (95% CI, 0.0%–0.3%).[13]
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The 25-year cumulative incidence of lung cancer among the DCOG-LATER cohort was 0.1% (95% CI, 0.0%–0.3%).[13]
Incidence was approximately fourfold higher than what would be expected in the general population (SIR, 4.3; 95% CI, 1.9–8.5).
Lung cancer has been reported after chest irradiation for Hodgkin lymphoma.[89]
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Lung cancer has been reported after chest irradiation for Hodgkin lymphoma.[89]
The risk increases in association with longer elapsed time from diagnosis.
Smoking has been linked with the occurrence of lung cancer that develops after radiation therapy for Hodgkin lymphoma.[89]
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Smoking has been linked with the occurrence of lung cancer that develops after radiation therapy for Hodgkin lymphoma.[89]
The increase in risk of lung cancer with increasing radiation dose is greater among patients who smoke after exposure to radiation than among those who refrain from smoking (P = .04).
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Preserved source evidence · Not medical advice