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Skin Lesions
Source: Langerhans Cell Histiocytosis Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: June 6, 2024 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.
Context: Treatment of Low-Risk LCH in Children
Treatment of newly diagnosed childhood Langerhans cell histiocytosis (LCH) skin lesions may include:
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Observation. Young children with skin-only LCH lesions should be followed over a period of many years due to a risk of diabetes insipidus.
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When severe rashes, pain, ulceration, or bleeding occur, treatment may include the following:
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Steroid therapy.
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Chemotherapy given by mouth or vein.
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Chemotherapy applied to the skin.
Photodynamic therapy with psoralen and ultraviolet A (PUVA) therapy.
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UVB radiation therapy.
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Preserved source evidence · Independent clinical review pending · Not medical advice