TriangleFOR PATIENTS · SOURCE READING
Lesions in Bones or Other Low-Risk Organs
Source: Langerhans Cell Histiocytosis Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: June 6, 2024 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.
Context: Treatment of Low-Risk LCH in Children
Treatment of newly diagnosed childhood LCH bone lesions in the front, sides, or back of the skull, or in any other single bone may include:
Surgery (curettage) with or without steroid therapy.
Source links and citations
Low-dose radiation therapy for lesions that affect nearby organs, or are painful and cannot be treated with other therapy.
Source links and citations
Treatment of newly diagnosed childhood LCH lesions in bones around the ears or eyes is done to lower the risk of diabetes insipidus and other long-term problems. Treatment may include:
Source links and citations
Chemotherapy and steroid therapy.
Source links and citations
Surgery (curettage).
Treatment of newly diagnosed childhood LCH lesions of the spine or thigh bone may include:
Source links and citations
Observation.
Source links and citations
Low-dose radiation therapy.
Chemotherapy, for lesions that spread from the spine into nearby tissue.
Source links and citations
Surgery to strengthen the weakened bone by bracing or fusing the bones together.
Treatment of two or more bone lesions may include:
Chemotherapy and steroid therapy.
Treatment of two or more bone lesions combined with skin lesions, lymph node lesions, or diabetes insipidus may include:
Source links and citations
Chemotherapy with or without steroid therapy.
Bisphosphonate therapy.
Source links and citations
Preserved source evidence · Independent clinical review pending · Not medical advice