Childhood Malignant Ovarian GCTs

Source: Childhood Extracranial Germ Cell Tumors Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: November 5, 2024 · Captured 2026-09-09.

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Context: Treatment of Malignant Gonadal GCTs in Children

Most ovarian neoplasms in children and adolescents are of germ cell origin.[19] Ovarian GCTs are very rare in young girls, but the incidence begins to increase in children aged approximately 8 or 9 years and continues to rise throughout adulthood.[1]

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Childhood malignant ovarian GCTs can be divided into germinomatous (dysgerminomas) and nongerminomatous malignant GCTs (i.e., yolk sac carcinomas, mixed GCTs, choriocarcinoma, and embryonal carcinomas).

For more information about childhood mature and immature teratomas arising in the ovary, see the Treatment of Mature Teratomas section. For more information about the treatment of ovarian GCT in postpubertal females, see Ovarian Germ Cell Tumors Treatment.

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Dysgerminomas of the ovary →Malignant nongerminomatous ovarian GCTs →Treatment options under clinical evaluation for malignant ovarian GCTs →

Preserved source evidence · Not medical advice