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← Childhood Extracranial Germ Cell Tumors

HEALTH PROFESSIONAL · SOURCE READING

Retroperitoneal site

Source: Childhood Extracranial Germ Cell Tumors Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: November 5, 2024 · Captured 2026-09-09.

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Context: Treatment of Malignant Extragonadal Extracranial GCTs in Children / Standard Treatment Options for Malignant Extragonadal Extracranial GCTs in Prepubertal Children / Site-specific considerations for malignant extragonadal extracranial GCTs

Malignant GCTs located in the retroperitoneum or abdomen usually present in children younger than 5 years. Most of these tumors are advanced stage and locally unresectable at diagnosis.[15] A limited biopsy followed by platinum-based chemotherapy to shrink tumor bulk can lead to complete tumor resection in most patients. Despite the advanced-stage disease in most patients, the 6-year EFS rate using PEb was 83% in the Pediatric Oncology Group/Children's Cancer Group intergroup study.[15]

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