Surgery and observation (stage I)

Source: Childhood Extracranial Germ Cell Tumors Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: November 5, 2024 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.

Context: Treatment of Malignant Gonadal GCTs in Children / Childhood Malignant Ovarian GCTs / Dysgerminomas of the ovary / Standard treatment options for dysgerminomas of the ovary

For stage I ovarian dysgerminomas, a cure can usually be achieved by unilateral salpingo-oophorectomy, conserving the uterus and opposite ovary, and close follow-up observation.[9,20-23]

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Evidence (surgery and observation for stage I dysgerminomas):

In three successive French Society of Pediatric Oncology studies (TGM-85, TGM-90, and TGM-95), the following was reported:[24][Level of evidence C1]

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In three successive French Society of Pediatric Oncology studies (TGM-85, TGM-90, and TGM-95), the following was reported:[24][Level of evidence C1]

Fifteen patients were identified as stage I, and all patients survived.

In three successive French Society of Pediatric Oncology studies (TGM-85, TGM-90, and TGM-95), the following was reported:[24][Level of evidence C1]

Before 1998, eight patients were treated with adjuvant radiation or chemotherapy. After a practice change in 1998, seven patients underwent surgery and observation.

In three successive French Society of Pediatric Oncology studies (TGM-85, TGM-90, and TGM-95), the following was reported:[24][Level of evidence C1]

One of the seven patients (14%) had a tumor event and responded to treatment with chemotherapy.

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Preserved source evidence · Not medical advice