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Surgery and observation for prepubertal females (stage I following strict surgical staging guidelines)
Source: Childhood Extracranial Germ Cell Tumors Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: November 5, 2024 · Captured 2026-09-09.
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When strict surgical staging guidelines are followed, surgery followed by observation may be an appropriate treatment choice for prepubertal females with stage I disease.
Evidence (surgery and observation for prepubertal females with stage I disease):
In a COG trial, 25 girls with stage I ovarian malignant GCTs were treated with surgery and observation.[34]
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In a COG trial, 25 girls with stage I ovarian malignant GCTs were treated with surgery and observation.[34]
The 4-year EFS rate was 52%.
In a COG trial, 25 girls with stage I ovarian malignant GCTs were treated with surgery and observation.[34]
Relapse was detected in 12 patients by tumor marker elevation (mean time, 2 months). All patients later received salvage therapy with three cycles of PEb. The 4-year OS rate was 96%; one patient's disease was not salvaged.
Similar results have been reported in other international pediatric trials, but the number of patients has been small.[9]
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Preserved source evidence · Not medical advice