HEALTH PROFESSIONAL · SOURCE READING
Local-Control Measures
Source: Ewing Sarcoma and Undifferentiated Small Round Cell Sarcomas of Bone and Soft Tissue Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: November 27, 2024 · Captured 2026-09-09.
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Context: Treatment of Localized Ewing Sarcoma
Local control can be achieved by surgery and/or radiation therapy. Decisions regarding the optimal modality for local control for an individual patient involve consideration of the following:
The possibility of complete resection with adequate margins after an initial period of systemic therapy.
The predicted functional impact of a surgical procedure.
The predicted morbidity after radiation therapy.
The possibility of increased risk of second malignant neoplasms after radiation therapy.
An analysis using propensity scoring (a method that adjusts for the inherent selection bias of the location and size of the tumor) to adjust for clinical features that may influence the preference for surgery only, radiation only, or combined surgery and radiation demonstrated that similar EFS rates are achieved with each mode of local therapy after propensity adjustment.[17]
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