Treatment of Recurrent Pediatric-Type Diffuse High-Grade Gliomas

Source: Childhood Astrocytomas, Other Gliomas, and Glioneuronal/Neuronal Tumors Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: April 14, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.

To determine and implement optimal management, treatment is best guided by a multidisciplinary team of specialists experienced in treating pediatric patients with brain tumors.

Treatment options for recurrent pediatric-type diffuse high-grade gliomas include the following:

Second surgery.

Source links and citations

Second surgery

Radiation therapy.

Source links and citations

Radiation therapy

Targeted therapy.

Source links and citations

Targeted therapy

Immunotherapy.

Source links and citations

Immunotherapy

Continue within this section

Second Surgery →Radiation Therapy →Targeted Therapy →Immunotherapy →Treatment Options Under Clinical Evaluation →

Preserved source evidence · Not medical advice