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← Bladder Cancer

HEALTH PROFESSIONAL · SOURCE READING

Treatment options for patients with T4b, N0, M0 disease

Source: Bladder Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: May 2, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.

Context: Treatment of Stage IV Bladder Cancer / Treatment Options for Stage IV Bladder Cancer

Treatment options for patients with T4b, N0, M0 disease include:

Enfortumab vedotin plus pembrolizumab.

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Chemotherapy plus immunotherapy.

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Chemotherapy alone.

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Systemic therapy followed by radical cystectomy.

External-beam radiation therapy (EBRT) with or without concomitant chemotherapy.

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Urinary diversion or cystectomy for palliation.

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Enfortumab vedotin plus pembrolizumab →Chemotherapy plus immunotherapy →Chemotherapy alone →External-beam radiation therapy (EBRT) with or without concomitant chemotherapy →Urinary diversion or cystectomy for palliation →

Preserved source evidence · Not medical advice