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NCT03762018 · ADVERSE EVENTS

Adverse events

BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural Mesothelioma · Source last updated 2026-07-22

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Adverse events occurred during the study; they are not necessarily caused by treatment. Serious events are not interchangeable with severe/grade 3–4 events. These safety populations may differ from efficacy populations.

Collection time frame
Adverse events were assessed from randomization until 90 days after the last dose of protocol treatment, up to 52 months.
Other-event reporting threshold
5%

Adverse event (AE) is defined as any untoward medical occurrence that occurs from randomization until 90 days after all trial treatment discontinuation, regardless of whether it is considered related to a medication. Adverse events are classified according to CTCAE version 5.0 and assessed in safety population (patients who received at least 1 dose of trial treatment: 199 in each arm). Of note, all-cause mortality was assessed for all randomized (200 in each arm).

Participants affected / participants at risk, as reported
Safety groupSerious eventsOther eventsDeaths
Atezolizumab Plus Bevacizumab Plus Chemotherapy

Atezolizumab 1200mg intravenously on day 1 every 3 weeks plus bevacizumab 15mg/kg intravenously on day 1 every 3 weeks plus 4-6 cycles of carboplatin AUC 5 plus pemetrexed 500mg/m\^2 intravenously on day 1 every 3 weeks

92 / 199197 / 199145 / 200
Bevacizumab Plus Chemotherapy

Bevacizumab 15mg/kg intravenously on day 1 every 3 weeks plus 4-6 cycles of carboplatin AUC 5 plus pemetrexed 500mg/m\^2 intravenously on day 1 every 3 weeks

67 / 199197 / 199150 / 200

Group identifiers: EG000: Atezolizumab Plus Bevacizumab Plus Chemotherapy · EG001: Bevacizumab Plus Chemotherapy

Serious adverse events

Event terms and counts are source-reported; expand to read more. A reporting threshold may omit less frequent events.

  1. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      5
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      2
      num At Risk
      199
    term
    Anemia
  2. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      6
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      2
      num At Risk
      199
    term
    Febrile neutropenia
  3. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Immune thrombo-cytopenic purpura
  4. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Pancytopenia
  5. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Asystole
  6. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      199
    term
    Atrial fibrillation
  7. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      199
    term
    Chest pain - cardiac
  8. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Heart failure
  9. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      3
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Myocardial infarction
  10. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      2
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Myocarditis
  11. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Supraventricular tachycardia
  12. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Ventricular arrhythmia

Other reported adverse events

Event terms and counts are source-reported; expand to read more. A reporting threshold may omit less frequent events.

  1. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    General disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      113
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      110
      num At Risk
      199
    term
    Fatigue
  2. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      84
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      93
      num At Risk
      199
    term
    Nausea
  3. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      83
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      81
      num At Risk
      199
    term
    Constipation
  4. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      73
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      71
      num At Risk
      199
    term
    Anemia
  5. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Vascular disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      73
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      62
      num At Risk
      199
    term
    Hypertension
  6. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Investigations
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      65
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      57
      num At Risk
      199
    term
    Neutrophil count decreased
  7. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Metabolism and nutrition disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      59
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      54
      num At Risk
      199
    term
    Anorexia
  8. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Respiratory, thoracic and mediastinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      56
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      56
      num At Risk
      199
    term
    Epistaxis
  9. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      65
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      47
      num At Risk
      199
    term
    Mucositis oral
  10. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      57
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      40
      num At Risk
      199
    term
    Diarrhea
  11. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Respiratory, thoracic and mediastinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      44
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      51
      num At Risk
      199
    term
    Dyspnea
  12. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    General disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      31
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      36
      num At Risk
      199
    term
    Non-cardiac chest pain
Complete source fields
description
Adverse event (AE) is defined as any untoward medical occurrence that occurs from randomization until 90 days after all trial treatment discontinuation, regardless of whether it is considered related to a medication. Adverse events are classified according to CTCAE version 5.0 and assessed in safety population (patients who received at least 1 dose of trial treatment: 199 in each arm). Of note, all-cause mortality was assessed for all randomized (200 in each arm).
event Groups
  1. deaths Num Affected
    145
    deaths Num At Risk
    200
    description
    Atezolizumab 1200mg intravenously on day 1 every 3 weeks plus bevacizumab 15mg/kg intravenously on day 1 every 3 weeks plus 4-6 cycles of carboplatin AUC 5 plus pemetrexed 500mg/m\^2 intravenously on day 1 every 3 weeks
    id
    EG000
    other Num Affected
    197
    other Num At Risk
    199
    serious Num Affected
    92
    serious Num At Risk
    199
    title
    Atezolizumab Plus Bevacizumab Plus Chemotherapy
  2. deaths Num Affected
    150
    deaths Num At Risk
    200
    description
    Bevacizumab 15mg/kg intravenously on day 1 every 3 weeks plus 4-6 cycles of carboplatin AUC 5 plus pemetrexed 500mg/m\^2 intravenously on day 1 every 3 weeks
    id
    EG001
    other Num Affected
    197
    other Num At Risk
    199
    serious Num Affected
    67
    serious Num At Risk
    199
    title
    Bevacizumab Plus Chemotherapy
frequency Threshold
5
other Events
  1. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    General disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      113
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      110
      num At Risk
      199
    term
    Fatigue
  2. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      84
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      93
      num At Risk
      199
    term
    Nausea
  3. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      83
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      81
      num At Risk
      199
    term
    Constipation
  4. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      73
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      71
      num At Risk
      199
    term
    Anemia
  5. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Vascular disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      73
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      62
      num At Risk
      199
    term
    Hypertension
  6. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Investigations
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      65
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      57
      num At Risk
      199
    term
    Neutrophil count decreased
  7. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Metabolism and nutrition disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      59
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      54
      num At Risk
      199
    term
    Anorexia
  8. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Respiratory, thoracic and mediastinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      56
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      56
      num At Risk
      199
    term
    Epistaxis
  9. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      65
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      47
      num At Risk
      199
    term
    Mucositis oral
  10. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Gastrointestinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      57
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      40
      num At Risk
      199
    term
    Diarrhea
  11. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Respiratory, thoracic and mediastinal disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      44
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      51
      num At Risk
      199
    term
    Dyspnea
  12. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    General disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      31
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      36
      num At Risk
      199
    term
    Non-cardiac chest pain
serious Events
  1. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      5
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      2
      num At Risk
      199
    term
    Anemia
  2. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      6
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      2
      num At Risk
      199
    term
    Febrile neutropenia
  3. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Immune thrombo-cytopenic purpura
  4. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Blood and lymphatic system disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Pancytopenia
  5. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Asystole
  6. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      199
    term
    Atrial fibrillation
  7. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      0
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      1
      num At Risk
      199
    term
    Chest pain - cardiac
  8. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Heart failure
  9. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      3
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Myocardial infarction
  10. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      2
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Myocarditis
  11. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Supraventricular tachycardia
  12. assessment Type
    SYSTEMATIC_ASSESSMENT
    organ System
    Cardiac disorders
    source Vocabulary
    CTCAE (v5.0)
    stats
    1. group Id
      EG000
      num Affected
      1
      num At Risk
      199
    2. group Id
      EG001
      num Affected
      0
      num At Risk
      199
    term
    Ventricular arrhythmia
time Frame
Adverse events were assessed from randomization until 90 days after the last dose of protocol treatment, up to 52 months.

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