{"description":"Adverse event (AE) is defined as any untoward medical occurrence that occurs from randomization until 90 days after all trial treatment discontinuation, regardless of whether it is considered related to a medication. Adverse events are classified according to CTCAE version 5.0 and assessed in safety population (patients who received at least 1 dose of trial treatment: 199 in each arm). Of note, all-cause mortality was assessed for all randomized (200 in each arm).","eventGroups":[{"deathsNumAffected":145,"deathsNumAtRisk":200,"description":"Atezolizumab 1200mg intravenously on day 1 every 3 weeks plus bevacizumab 15mg/kg intravenously on day 1 every 3 weeks plus 4-6 cycles of carboplatin AUC 5 plus pemetrexed 500mg/m\\^2 intravenously on day 1 every 3 weeks","id":"EG000","otherNumAffected":197,"otherNumAtRisk":199,"seriousNumAffected":92,"seriousNumAtRisk":199,"title":"Atezolizumab Plus Bevacizumab Plus Chemotherapy"},{"deathsNumAffected":150,"deathsNumAtRisk":200,"description":"Bevacizumab 15mg/kg intravenously on day 1 every 3 weeks plus 4-6 cycles of carboplatin AUC 5 plus pemetrexed 500mg/m\\^2 intravenously on day 1 every 3 weeks","id":"EG001","otherNumAffected":197,"otherNumAtRisk":199,"seriousNumAffected":67,"seriousNumAtRisk":199,"title":"Bevacizumab Plus Chemotherapy"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":113,"numAtRisk":199},{"groupId":"EG001","numAffected":110,"numAtRisk":199}],"term":"Fatigue"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":84,"numAtRisk":199},{"groupId":"EG001","numAffected":93,"numAtRisk":199}],"term":"Nausea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":83,"numAtRisk":199},{"groupId":"EG001","numAffected":81,"numAtRisk":199}],"term":"Constipation"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":73,"numAtRisk":199},{"groupId":"EG001","numAffected":71,"numAtRisk":199}],"term":"Anemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":73,"numAtRisk":199},{"groupId":"EG001","numAffected":62,"numAtRisk":199}],"term":"Hypertension"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":65,"numAtRisk":199},{"groupId":"EG001","numAffected":57,"numAtRisk":199}],"term":"Neutrophil count decreased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":59,"numAtRisk":199},{"groupId":"EG001","numAffected":54,"numAtRisk":199}],"term":"Anorexia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":56,"numAtRisk":199},{"groupId":"EG001","numAffected":56,"numAtRisk":199}],"term":"Epistaxis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":65,"numAtRisk":199},{"groupId":"EG001","numAffected":47,"numAtRisk":199}],"term":"Mucositis oral"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":57,"numAtRisk":199},{"groupId":"EG001","numAffected":40,"numAtRisk":199}],"term":"Diarrhea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"CTCAE 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(v5.0)","stats":[{"groupId":"EG000","numAffected":33,"numAtRisk":199},{"groupId":"EG001","numAffected":33,"numAtRisk":199}],"term":"Cough"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":39,"numAtRisk":199},{"groupId":"EG001","numAffected":24,"numAtRisk":199}],"term":"Creatinine increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":43,"numAtRisk":199},{"groupId":"EG001","numAffected":17,"numAtRisk":199}],"term":"Fever"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"CTCAE (v5.0)","stats":[{"groupId":"EG000","numAffected":35,"numAtRisk":199},{"groupId":"EG001","numAffected":24,"numAtRisk":199}],"term":"Pruritus"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal 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