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NCT02460224 · BASELINE

Baseline characteristics

Safety and Efficacy of LAG525 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies. · Source last updated 2022-02-10

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

denoms
  1. counts
    1. group Id
      BG000
      value
      17
    2. group Id
      BG001
      value
      12
    3. group Id
      BG002
      value
      6
    4. group Id
      BG003
      value
      6
    5. group Id
      BG004
      value
      6
    6. group Id
      BG005
      value
      30
    7. group Id
      BG006
      value
      30
    8. group Id
      BG007
      value
      5
    9. group Id
      BG008
      value
      6
    10. group Id
      BG009
      value
      11
    11. group Id
      BG010
      value
      5
    12. group Id
      BG011
      value
      6
    units
    Participants
groups
  1. description
    Single-agent LAG525 1 mg/kg Q2W
    id
    BG000
    title
    Phase 1: LAG525 1 mg/kg Q2W
  2. description
    Single-agent LAG525 3 mg/kg Q2W
    id
    BG001
    title
    Phase 1: LAG525 3 mg/kg Q2W
  3. description
    Single-agent LAG525 5 mg/kg Q2W
    id
    BG002
    title
    Phase 1: LAG525 5 mg/kg Q2W
  4. description
    Single-agent LAG525 10 mg/kg Q2W
    id
    BG003
    title
    Phase 1: LAG525 10 mg/kg Q2W
  5. description
    Single-agent LAG525 15 mg/kg Q2W
    id
    BG004
    title
    Phase 1: LAG525 15 mg/kg Q2W
  6. description
    Single-agent LAG525 240 mg Q2W
    id
    BG005
    title
    Phase 1: LAG525 240 mg Q2W
  7. description
    Single-agent LAG525 400 mg Q2W
    id
    BG006
    title
    Phase 1: LAG525 400 mg Q2W
  8. description
    Single-agent LAG525 3 mg/kg Q4W
    id
    BG007
    title
    Phase 1: LAG525 3 mg/kg Q4W
  9. description
    Single-agent LAG525 5 mg/kg Q4W
    id
    BG008
    title
    Phase 1: LAG525 5 mg/kg Q4W
  10. description
    Single-agent LAG525 10 mg/kg Q4W
    id
    BG009
    title
    Phase 1: LAG525 10 mg/kg Q4W
  11. description
    Single-agent LAG525 400 mg Q4W
    id
    BG010
    title
    Phase 1: LAG525 400 mg Q4W
  12. description
    Combination LAG525 0.3 mg/kg + PDR001 1 mg/kg (Q2W/Q2W)
    id
    BG011
    title
    Phase 1: LAG525 0.3 mg/kg Q2W + PDR001 1 mg/kg Q2W
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          12.55
          value
          56.1
        2. group Id
          BG001
          spread
          12.43
          value
          64.5
        3. group Id
          BG002
          spread
          13.32
          value
          61.8
        4. group Id
          BG003
          spread
          20.76
          value
          53.3
        5. group Id
          BG004
          spread
          9.58
          value
          61.2
        6. group Id
          BG005
          spread
          10.94
          value
          57.2
        7. group Id
          BG006
          spread
          10.82
          value
          56.7
        8. group Id
          BG007
          spread
          9.36
          value
          60.8
        9. group Id
          BG008
          spread
          17.26
          value
          54.8
        10. group Id
          BG009
          spread
          7.16
          value
          59.5
        11. group Id
          BG010
          spread
          7.16
          value
          60.4
        12. group Id
          BG011
          spread
          8.78
          value
          54.3
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          7
        2. group Id
          BG001
          value
          6
        3. group Id
          BG002
          value
          3
        4. group Id
          BG003
          value
          4
        5. group Id
          BG004
          value
          4
        6. group Id
          BG005
          value
          17
        7. group Id
          BG006
          value
          14
        8. group Id
          BG007
          value
          2
        9. group Id
          BG008
          value
          4
        10. group Id
          BG009
          value
          6
        11. group Id
          BG010
          value
          2
        12. group Id
          BG011
          value
          3
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          10
        2. group Id
          BG001
          value
          6
        3. group Id
          BG002
          value
          3
        4. group Id
          BG003
          value
          2
        5. group Id
          BG004
          value
          2
        6. group Id
          BG005
          value
          13
        7. group Id
          BG006
          value
          16
        8. group Id
          BG007
          value
          3
        9. group Id
          BG008
          value
          2
        10. group Id
          BG009
          value
          5
        11. group Id
          BG010
          value
          3
        12. group Id
          BG011
          value
          3
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          8
        2. group Id
          BG001
          value
          9
        3. group Id
          BG002
          value
          5
        4. group Id
          BG003
          value
          3
        5. group Id
          BG004
          value
          6
        6. group Id
          BG005
          value
          20
        7. group Id
          BG006
          value
          20
        8. group Id
          BG007
          value
          2
        9. group Id
          BG008
          value
          4
        10. group Id
          BG009
          value
          10
        11. group Id
          BG010
          value
          3
        12. group Id
          BG011
          value
          2
        title
        Caucasian
      2. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          0
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          0
        12. group Id
          BG011
          value
          0
        title
        Black
      3. measurements
        1. group Id
          BG000
          value
          8
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          3
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          10
        7. group Id
          BG006
          value
          10
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          1
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          2
        12. group Id
          BG011
          value
          3
        title
        Asian
      4. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          0
        9. group Id
          BG008
          value
          0
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          0
        12. group Id
          BG011
          value
          0
        title
        Pacific Islander
      5. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          0
        9. group Id
          BG008
          value
          1
        10. group Id
          BG009
          value
          1
        11. group Id
          BG010
          value
          0
        12. group Id
          BG011
          value
          1
        title
        Unknown
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          0
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          0
        12. group Id
          BG011
          value
          0
        title
        Other
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants
Complete source fields
denoms
  1. counts
    1. group Id
      BG000
      value
      17
    2. group Id
      BG001
      value
      12
    3. group Id
      BG002
      value
      6
    4. group Id
      BG003
      value
      6
    5. group Id
      BG004
      value
      6
    6. group Id
      BG005
      value
      30
    7. group Id
      BG006
      value
      30
    8. group Id
      BG007
      value
      5
    9. group Id
      BG008
      value
      6
    10. group Id
      BG009
      value
      11
    11. group Id
      BG010
      value
      5
    12. group Id
      BG011
      value
      6
    units
    Participants
groups
  1. description
    Single-agent LAG525 1 mg/kg Q2W
    id
    BG000
    title
    Phase 1: LAG525 1 mg/kg Q2W
  2. description
    Single-agent LAG525 3 mg/kg Q2W
    id
    BG001
    title
    Phase 1: LAG525 3 mg/kg Q2W
  3. description
    Single-agent LAG525 5 mg/kg Q2W
    id
    BG002
    title
    Phase 1: LAG525 5 mg/kg Q2W
  4. description
    Single-agent LAG525 10 mg/kg Q2W
    id
    BG003
    title
    Phase 1: LAG525 10 mg/kg Q2W
  5. description
    Single-agent LAG525 15 mg/kg Q2W
    id
    BG004
    title
    Phase 1: LAG525 15 mg/kg Q2W
  6. description
    Single-agent LAG525 240 mg Q2W
    id
    BG005
    title
    Phase 1: LAG525 240 mg Q2W
  7. description
    Single-agent LAG525 400 mg Q2W
    id
    BG006
    title
    Phase 1: LAG525 400 mg Q2W
  8. description
    Single-agent LAG525 3 mg/kg Q4W
    id
    BG007
    title
    Phase 1: LAG525 3 mg/kg Q4W
  9. description
    Single-agent LAG525 5 mg/kg Q4W
    id
    BG008
    title
    Phase 1: LAG525 5 mg/kg Q4W
  10. description
    Single-agent LAG525 10 mg/kg Q4W
    id
    BG009
    title
    Phase 1: LAG525 10 mg/kg Q4W
  11. description
    Single-agent LAG525 400 mg Q4W
    id
    BG010
    title
    Phase 1: LAG525 400 mg Q4W
  12. description
    Combination LAG525 0.3 mg/kg + PDR001 1 mg/kg (Q2W/Q2W)
    id
    BG011
    title
    Phase 1: LAG525 0.3 mg/kg Q2W + PDR001 1 mg/kg Q2W
measures
  1. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          spread
          12.55
          value
          56.1
        2. group Id
          BG001
          spread
          12.43
          value
          64.5
        3. group Id
          BG002
          spread
          13.32
          value
          61.8
        4. group Id
          BG003
          spread
          20.76
          value
          53.3
        5. group Id
          BG004
          spread
          9.58
          value
          61.2
        6. group Id
          BG005
          spread
          10.94
          value
          57.2
        7. group Id
          BG006
          spread
          10.82
          value
          56.7
        8. group Id
          BG007
          spread
          9.36
          value
          60.8
        9. group Id
          BG008
          spread
          17.26
          value
          54.8
        10. group Id
          BG009
          spread
          7.16
          value
          59.5
        11. group Id
          BG010
          spread
          7.16
          value
          60.4
        12. group Id
          BG011
          spread
          8.78
          value
          54.3
    dispersion Type
    STANDARD_DEVIATION
    param Type
    MEAN
    title
    Age, Continuous
    unit Of Measure
    years
  2. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          7
        2. group Id
          BG001
          value
          6
        3. group Id
          BG002
          value
          3
        4. group Id
          BG003
          value
          4
        5. group Id
          BG004
          value
          4
        6. group Id
          BG005
          value
          17
        7. group Id
          BG006
          value
          14
        8. group Id
          BG007
          value
          2
        9. group Id
          BG008
          value
          4
        10. group Id
          BG009
          value
          6
        11. group Id
          BG010
          value
          2
        12. group Id
          BG011
          value
          3
        title
        Female
      2. measurements
        1. group Id
          BG000
          value
          10
        2. group Id
          BG001
          value
          6
        3. group Id
          BG002
          value
          3
        4. group Id
          BG003
          value
          2
        5. group Id
          BG004
          value
          2
        6. group Id
          BG005
          value
          13
        7. group Id
          BG006
          value
          16
        8. group Id
          BG007
          value
          3
        9. group Id
          BG008
          value
          2
        10. group Id
          BG009
          value
          5
        11. group Id
          BG010
          value
          3
        12. group Id
          BG011
          value
          3
        title
        Male
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Sex: Female, Male
    unit Of Measure
    Participants
  3. classes
    1. categories
      1. measurements
        1. group Id
          BG000
          value
          8
        2. group Id
          BG001
          value
          9
        3. group Id
          BG002
          value
          5
        4. group Id
          BG003
          value
          3
        5. group Id
          BG004
          value
          6
        6. group Id
          BG005
          value
          20
        7. group Id
          BG006
          value
          20
        8. group Id
          BG007
          value
          2
        9. group Id
          BG008
          value
          4
        10. group Id
          BG009
          value
          10
        11. group Id
          BG010
          value
          3
        12. group Id
          BG011
          value
          2
        title
        Caucasian
      2. measurements
        1. group Id
          BG000
          value
          1
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          0
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          0
        12. group Id
          BG011
          value
          0
        title
        Black
      3. measurements
        1. group Id
          BG000
          value
          8
        2. group Id
          BG001
          value
          2
        3. group Id
          BG002
          value
          1
        4. group Id
          BG003
          value
          3
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          10
        7. group Id
          BG006
          value
          10
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          1
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          2
        12. group Id
          BG011
          value
          3
        title
        Asian
      4. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          0
        9. group Id
          BG008
          value
          0
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          0
        12. group Id
          BG011
          value
          0
        title
        Pacific Islander
      5. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          0
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          0
        9. group Id
          BG008
          value
          1
        10. group Id
          BG009
          value
          1
        11. group Id
          BG010
          value
          0
        12. group Id
          BG011
          value
          1
        title
        Unknown
      6. measurements
        1. group Id
          BG000
          value
          0
        2. group Id
          BG001
          value
          1
        3. group Id
          BG002
          value
          0
        4. group Id
          BG003
          value
          0
        5. group Id
          BG004
          value
          0
        6. group Id
          BG005
          value
          0
        7. group Id
          BG006
          value
          0
        8. group Id
          BG007
          value
          1
        9. group Id
          BG008
          value
          0
        10. group Id
          BG009
          value
          0
        11. group Id
          BG010
          value
          0
        12. group Id
          BG011
          value
          0
        title
        Other
    param Type
    COUNT_OF_PARTICIPANTS
    title
    Race/Ethnicity, Customized
    unit Of Measure
    Participants

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Preserved source evidence · Not medical advice