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NCT02264613 · FLOW

Participant flow

ALRN-6924 in Patients With Advanced Solid Tumors or Lymphomas · Source last updated 2026-01-13

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

groups
  1. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG000
    title
    Dose Regimen A (DR-A) Escalation (0.16 mg/kg)
  2. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG001
    title
    Dose Regimen A (DR-A) Escalation (0.32 mg/kg)
  3. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG002
    title
    Dose Regimen A (DR-A) Escalation (0.64 mg/kg)
  4. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG003
    title
    Dose Regimen A (DR-A) Escalation (1.25 mg/kg)
  5. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG004
    title
    Dose Regimen A (DR-A) Escalation (2.10 mg/kg)
  6. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG005
    title
    Dose Regiment A (DR-A) Escalation (3.10 mg/kg)
  7. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG006
    title
    Dose Regimen A (DR-A) Escalation (4.40 mg/kg)
  8. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 4, 8 and 11 of a 21-day cycle ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG007
    title
    Dose Regimen B (DR-B) Escalation (0.32 mg/kg)
  9. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG008
    title
    Dose Regimen B (DR-B) Escalation (0.53 mg/kg)
  10. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG009
    title
    Dose Regimen B (DR-B) Escalation (0.80 mg/kg)
  11. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG010
    title
    Dose Regimen B (DR-B) Escalation (1.10 mg/kg)
  12. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG011
    title
    Dose Regimen B (DR-B) Escalation (1.50 mg/kg)
periods
  1. milestones
    1. achievements
      1. group Id
        FG000
        num Subjects
        5
      2. group Id
        FG001
        num Subjects
        3
      3. group Id
        FG002
        num Subjects
        4
      4. group Id
        FG003
        num Subjects
        3
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        9
      7. group Id
        FG006
        num Subjects
        11
      8. group Id
        FG007
        num Subjects
        3
      9. group Id
        FG008
        num Subjects
        5
      10. group Id
        FG009
        num Subjects
        3
      11. group Id
        FG010
        num Subjects
        4
      12. group Id
        FG011
        num Subjects
        4
      type
      STARTED
    2. achievements
      1. group Id
        FG000
        num Subjects
        0
      2. group Id
        FG001
        num Subjects
        0
      3. group Id
        FG002
        num Subjects
        0
      4. group Id
        FG003
        num Subjects
        1
      5. group Id
        FG004
        num Subjects
        1
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        1
      8. group Id
        FG007
        num Subjects
        0
      9. group Id
        FG008
        num Subjects
        0
      10. group Id
        FG009
        num Subjects
        0
      11. group Id
        FG010
        num Subjects
        0
      12. group Id
        FG011
        num Subjects
        0
      type
      COMPLETED
    3. achievements
      1. group Id
        FG000
        num Subjects
        5
      2. group Id
        FG001
        num Subjects
        3
      3. group Id
        FG002
        num Subjects
        4
      4. group Id
        FG003
        num Subjects
        2
      5. group Id
        FG004
        num Subjects
        5
      6. group Id
        FG005
        num Subjects
        9
      7. group Id
        FG006
        num Subjects
        10
      8. group Id
        FG007
        num Subjects
        3
      9. group Id
        FG008
        num Subjects
        5
      10. group Id
        FG009
        num Subjects
        3
      11. group Id
        FG010
        num Subjects
        4
      12. group Id
        FG011
        num Subjects
        4
      type
      NOT COMPLETED
    title
    Overall Study
Complete source fields
groups
  1. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG000
    title
    Dose Regimen A (DR-A) Escalation (0.16 mg/kg)
  2. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG001
    title
    Dose Regimen A (DR-A) Escalation (0.32 mg/kg)
  3. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG002
    title
    Dose Regimen A (DR-A) Escalation (0.64 mg/kg)
  4. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG003
    title
    Dose Regimen A (DR-A) Escalation (1.25 mg/kg)
  5. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG004
    title
    Dose Regimen A (DR-A) Escalation (2.10 mg/kg)
  6. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG005
    title
    Dose Regiment A (DR-A) Escalation (3.10 mg/kg)
  7. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG006
    title
    Dose Regimen A (DR-A) Escalation (4.40 mg/kg)
  8. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 4, 8 and 11 of a 21-day cycle ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG007
    title
    Dose Regimen B (DR-B) Escalation (0.32 mg/kg)
  9. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG008
    title
    Dose Regimen B (DR-B) Escalation (0.53 mg/kg)
  10. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG009
    title
    Dose Regimen B (DR-B) Escalation (0.80 mg/kg)
  11. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG010
    title
    Dose Regimen B (DR-B) Escalation (1.10 mg/kg)
  12. description
    Drug: ALRN-6924 Weight-based-dosing administered IV on days 1, 8 and 15 of a 28-day cycle. ALRN-6924: ALRN-6924 will be administered as an IV infusion
    id
    FG011
    title
    Dose Regimen B (DR-B) Escalation (1.50 mg/kg)
periods
  1. milestones
    1. achievements
      1. group Id
        FG000
        num Subjects
        5
      2. group Id
        FG001
        num Subjects
        3
      3. group Id
        FG002
        num Subjects
        4
      4. group Id
        FG003
        num Subjects
        3
      5. group Id
        FG004
        num Subjects
        6
      6. group Id
        FG005
        num Subjects
        9
      7. group Id
        FG006
        num Subjects
        11
      8. group Id
        FG007
        num Subjects
        3
      9. group Id
        FG008
        num Subjects
        5
      10. group Id
        FG009
        num Subjects
        3
      11. group Id
        FG010
        num Subjects
        4
      12. group Id
        FG011
        num Subjects
        4
      type
      STARTED
    2. achievements
      1. group Id
        FG000
        num Subjects
        0
      2. group Id
        FG001
        num Subjects
        0
      3. group Id
        FG002
        num Subjects
        0
      4. group Id
        FG003
        num Subjects
        1
      5. group Id
        FG004
        num Subjects
        1
      6. group Id
        FG005
        num Subjects
        0
      7. group Id
        FG006
        num Subjects
        1
      8. group Id
        FG007
        num Subjects
        0
      9. group Id
        FG008
        num Subjects
        0
      10. group Id
        FG009
        num Subjects
        0
      11. group Id
        FG010
        num Subjects
        0
      12. group Id
        FG011
        num Subjects
        0
      type
      COMPLETED
    3. achievements
      1. group Id
        FG000
        num Subjects
        5
      2. group Id
        FG001
        num Subjects
        3
      3. group Id
        FG002
        num Subjects
        4
      4. group Id
        FG003
        num Subjects
        2
      5. group Id
        FG004
        num Subjects
        5
      6. group Id
        FG005
        num Subjects
        9
      7. group Id
        FG006
        num Subjects
        10
      8. group Id
        FG007
        num Subjects
        3
      9. group Id
        FG008
        num Subjects
        5
      10. group Id
        FG009
        num Subjects
        3
      11. group Id
        FG010
        num Subjects
        4
      12. group Id
        FG011
        num Subjects
        4
      type
      NOT COMPLETED
    title
    Overall Study

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Preserved source evidence · Not medical advice