TriangleNCT01801436 · OUTCOME
Terminal Rate Constant (Lambda[z]) of Bortezomib on Day 11 of Cycle 1
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- MEAN
- Unit
- Per Hour
- Interval / dispersion
- Standard Deviation
- Time frame
- 0 hour (Pre-dose) and 0.08, 0.25, 0.5, 1, 2, 4, 6, 8, 12, 24, 48, 72 hours (post-dose) on Day 11 of Cycle 1
What was measured
Lambda(z) is defined as terminal rate-constant which reflect the speed of drug elimination in vivo (within the living), and is estimated by log-linear regression analysis of the terminal phase of the plasma concentration versus time curve for at least 3 points.
Analysis population: The PP population included all the participants who received study medications as per the administration schedule and for whom blood samples were collected at all scheduled time points.
Groups in this outcome
Bortezomib
Participants received 1.3 mg per m\^2 of bortezomib on Days 1, 4, 8, and 11 of each 3-week cycle for up to 8 cycles.
| Group | Source count |
|---|---|
| Bortezomib | 10 |
Reported measurements
Source class 1
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Bortezomib | 0.01 | 0.01 | Not reported | Not reported | Not reported |
Complete source fields
- classes
- categories
- measurements
- group Id
- OG000
- spread
- 0.01
- value
- 0.01
- denoms
- counts
- group Id
- OG000
- value
- 10
- units
- Participants
- description
- Lambda(z) is defined as terminal rate-constant which reflect the speed of drug elimination in vivo (within the living), and is estimated by log-linear regression analysis of the terminal phase of the plasma concentration versus time curve for at least 3 points.
- dispersion Type
- Standard Deviation
- groups
- description
- Participants received 1.3 mg per m\^2 of bortezomib on Days 1, 4, 8, and 11 of each 3-week cycle for up to 8 cycles.
- id
- OG000
- title
- Bortezomib
- param Type
- MEAN
- population Description
- The PP population included all the participants who received study medications as per the administration schedule and for whom blood samples were collected at all scheduled time points.
- reporting Status
- POSTED
- time Frame
- 0 hour (Pre-dose) and 0.08, 0.25, 0.5, 1, 2, 4, 6, 8, 12, 24, 48, 72 hours (post-dose) on Day 11 of Cycle 1
- title
- Terminal Rate Constant (Lambda[z]) of Bortezomib on Day 11 of Cycle 1
- type
- PRIMARY
- unit Of Measure
- Per Hour
Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f
Preserved source evidence · Not medical advice