TriangleNCT01237054 · OUTCOME
Comparison of Microvessel Density (MVD) Among Patients With MGUS, SMM, and MM
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- MEDIAN
- Unit
- microvessels/hpf
- Interval / dispersion
- Full Range
- Time frame
- 60 days
What was measured
Microvessel density was estimated by determining the average number of cluster of differentiation 34 (CD34)-stained microvessels in 10 areas of maximal MVD counted at a high-power field (h.p.f. x 500 magnification). Large vessels and vessels in the periosteum on bone were excluded. Areas of staining with no discrete breaks were counted as a single vessel. The presence of a lumen was not required.
Analysis population: Three patients with MM did not undergo bone marrow biopsies and were not included in this analysis.
Groups in this outcome
MGUS (Monoclonal Gammopathy of Undetermined Significance)
MGUS (Monoclonal gammopathy of undetermined significance) is a premalignant plasma cell proliferative disorder.
SMM (Smoldering Multiple Myeloma)
Smoldering multiple myeloma (SMM)is a premalignant plasma cell proliferative disorder.
MM (Multiple Myeloma)
Multiple myeloma is a plasma cell neoplasm.
| Group | Source count |
|---|---|
| MGUS (Monoclonal Gammopathy of Undetermined Significance) | 10 |
| SMM (Smoldering Multiple Myeloma) | 10 |
| MM (Multiple Myeloma) | 7 |
Reported measurements
Source class 1
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| MGUS (Monoclonal Gammopathy of Undetermined Significance) | 15 | Not reported | 15 | 19.7 | Not reported |
| SMM (Smoldering Multiple Myeloma) | 19.4 | Not reported | 7.6 | 32.5 | Not reported |
| MM (Multiple Myeloma) | 20.9 | Not reported | 10.5 | 37.6 | Not reported |
Source statistical analyses
- group Ids
- OG000
- OG001
- OG002
- non Inferiority Comment
- Other, trend test.
- non Inferiority Type
- OTHER
- p Value
- 0.008
- statistical Method
- Jonckheere-Terpstra test for trend
Complete source fields
- analyses
- group Ids
- OG000
- OG001
- OG002
- non Inferiority Comment
- Other, trend test.
- non Inferiority Type
- OTHER
- p Value
- 0.008
- statistical Method
- Jonckheere-Terpstra test for trend
- classes
- categories
- measurements
- group Id
- OG000
- lower Limit
- 15
- upper Limit
- 19.7
- value
- 15
- group Id
- OG001
- lower Limit
- 7.6
- upper Limit
- 32.5
- value
- 19.4
- group Id
- OG002
- lower Limit
- 10.5
- upper Limit
- 37.6
- value
- 20.9
- denoms
- counts
- group Id
- OG000
- value
- 10
- group Id
- OG001
- value
- 10
- group Id
- OG002
- value
- 7
- units
- Participants
- description
- Microvessel density was estimated by determining the average number of cluster of differentiation 34 (CD34)-stained microvessels in 10 areas of maximal MVD counted at a high-power field (h.p.f. x 500 magnification). Large vessels and vessels in the periosteum on bone were excluded. Areas of staining with no discrete breaks were counted as a single vessel. The presence of a lumen was not required.
- dispersion Type
- Full Range
- groups
- description
- MGUS (Monoclonal gammopathy of undetermined significance) is a premalignant plasma cell proliferative disorder.
- id
- OG000
- title
- MGUS (Monoclonal Gammopathy of Undetermined Significance)
- description
- Smoldering multiple myeloma (SMM)is a premalignant plasma cell proliferative disorder.
- id
- OG001
- title
- SMM (Smoldering Multiple Myeloma)
- description
- Multiple myeloma is a plasma cell neoplasm.
- id
- OG002
- title
- MM (Multiple Myeloma)
- param Type
- MEDIAN
- population Description
- Three patients with MM did not undergo bone marrow biopsies and were not included in this analysis.
- reporting Status
- POSTED
- time Frame
- 60 days
- title
- Comparison of Microvessel Density (MVD) Among Patients With MGUS, SMM, and MM
- type
- SECONDARY
- unit Of Measure
- microvessels/hpf
Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f
Preserved source evidence · Not medical advice