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NCT00666978 · OUTCOME

Number of Slow and Fast Metabolizers by Genotype

Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking · Source last updated 2017-11-13

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
COUNT_OF_PARTICIPANTS
Unit
Participants
Interval / dispersion
Not reported
Time frame
Week 0

What was measured

Analyzed CYP2A6 by genotype. The variants present in people in the slow genotype group include \*17, \*20, \*23,\*27, \*35, \*9, \*2, \*25, \*26, and \*4. The fast metabolizers have none of the variant alleles tested. Slow metabolizers have any reduction or loss of function variant. Fast metabolizers are \*1/\*1 genotype by exclusion.

Analysis population: This variant is related to nicotine metabolism and was collected from all study participants but not analyzed by study arm as it does not relate to the study medication. Data pre-specified to be collected and reported as a single arm. Blood was unable to be analyzed for CYP2A6 genotype for 6 participants.

Groups in this outcome

All Study Participants

All study participants were African American adults and received either bupropion (150mg bid) for 7 weeks in addition to health education counseling or placebo for 7 weeks in addition to health education counseling.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
All Study Participants534

Reported measurements

Slow Metabolizers by Genotype
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Study Participants265Not reportedNot reportedNot reportedNot reported
Fast Metabolizers by Genotype
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Study Participants269Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        265
    title
    Slow Metabolizers by Genotype
  2. categories
    1. measurements
      1. group Id
        OG000
        value
        269
    title
    Fast Metabolizers by Genotype
denoms
  1. counts
    1. group Id
      OG000
      value
      534
    units
    Participants
description
Analyzed CYP2A6 by genotype. The variants present in people in the slow genotype group include \*17, \*20, \*23,\*27, \*35, \*9, \*2, \*25, \*26, and \*4. The fast metabolizers have none of the variant alleles tested. Slow metabolizers have any reduction or loss of function variant. Fast metabolizers are \*1/\*1 genotype by exclusion.
groups
  1. description
    All study participants were African American adults and received either bupropion (150mg bid) for 7 weeks in addition to health education counseling or placebo for 7 weeks in addition to health education counseling.
    id
    OG000
    title
    All Study Participants
param Type
COUNT_OF_PARTICIPANTS
population Description
This variant is related to nicotine metabolism and was collected from all study participants but not analyzed by study arm as it does not relate to the study medication. Data pre-specified to be collected and reported as a single arm. Blood was unable to be analyzed for CYP2A6 genotype for 6 participants.
reporting Status
POSTED
time Frame
Week 0
title
Number of Slow and Fast Metabolizers by Genotype
type
SECONDARY
unit Of Measure
Participants

Download exact source JSON → · Snapshot ctgov-results-25a395029948b04d52b1253f

Preserved source evidence · Not medical advice