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NCT00346164 · OUTCOME

Degree of Agreement in Histologic Grade Between Pediatric Oncology Group (POG) and Fédération Nationale Des Centres de Lutte Contre le Cancer (FNCLCC) Pathologic Grading Systems

Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma · Source last updated 2022-04-28

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
COUNT_OF_PARTICIPANTS
Unit
Participants
Interval / dispersion
Not reported
Time frame
At diagnosis

What was measured

POG and FNCLCC grades were determined by pathologists based on published standards. A higher grade is associated with a more severe disease.

Analysis population: Ineligible patients, as well as patients without histologic grade determined by POG or FNCLCC were excluded. The OM evaluates the degree of agreement of two pathology grading systems applied at diagnosis. The time frame "At diagnosis" reflects the OM.

Groups in this outcome

Histologic Grade 1 by FNCLCC

Not reported

Histologic Grade 2 by FNCLCC

Not reported

Histologic Grade 3 by FNCLCC

Not reported

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Histologic Grade 1 by FNCLCC79
Histologic Grade 2 by FNCLCC222
Histologic Grade 3 by FNCLCC241

Reported measurements

Histologic grade 1 by POG
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Histologic Grade 1 by FNCLCC46Not reportedNot reportedNot reportedNot reported
Histologic Grade 2 by FNCLCC8Not reportedNot reportedNot reportedNot reported
Histologic Grade 3 by FNCLCC1Not reportedNot reportedNot reportedNot reported
Histologic grade 2 by POG
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Histologic Grade 1 by FNCLCC24Not reportedNot reportedNot reportedNot reported
Histologic Grade 2 by FNCLCC69Not reportedNot reportedNot reportedNot reported
Histologic Grade 3 by FNCLCC0Not reportedNot reportedNot reportedNot reported
Histologic grade 3 by POG
Values in Participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
Histologic Grade 1 by FNCLCC9Not reportedNot reportedNot reportedNot reported
Histologic Grade 2 by FNCLCC145Not reportedNot reportedNot reportedNot reported
Histologic Grade 3 by FNCLCC240Not reportedNot reportedNot reportedNot reported

Source statistical analyses

Group order, estimate direction, methods and comments are retained. No treatment ranking is inferred.

  1. ci Lower Limit
    0.36
    ci Num Sides
    TWO_SIDED
    ci Pct Value
    95
    ci Upper Limit
    0.48
    group Description
    Kappa statistic and its 95% confidence interval are used to assess agreement beyond random.
    group Ids
    1. OG000
    2. OG001
    3. OG002
    non Inferiority Type
    OTHER
    param Type
    Kappa statistic
    param Value
    0.42
Complete source fields
analyses
  1. ci Lower Limit
    0.36
    ci Num Sides
    TWO_SIDED
    ci Pct Value
    95
    ci Upper Limit
    0.48
    group Description
    Kappa statistic and its 95% confidence interval are used to assess agreement beyond random.
    group Ids
    1. OG000
    2. OG001
    3. OG002
    non Inferiority Type
    OTHER
    param Type
    Kappa statistic
    param Value
    0.42
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        46
      2. group Id
        OG001
        value
        8
      3. group Id
        OG002
        value
        1
    title
    Histologic grade 1 by POG
  2. categories
    1. measurements
      1. group Id
        OG000
        value
        24
      2. group Id
        OG001
        value
        69
      3. group Id
        OG002
        value
        0
    title
    Histologic grade 2 by POG
  3. categories
    1. measurements
      1. group Id
        OG000
        value
        9
      2. group Id
        OG001
        value
        145
      3. group Id
        OG002
        value
        240
    title
    Histologic grade 3 by POG
denoms
  1. counts
    1. group Id
      OG000
      value
      79
    2. group Id
      OG001
      value
      222
    3. group Id
      OG002
      value
      241
    units
    Participants
description
POG and FNCLCC grades were determined by pathologists based on published standards. A higher grade is associated with a more severe disease.
groups
  1. id
    OG000
    title
    Histologic Grade 1 by FNCLCC
  2. id
    OG001
    title
    Histologic Grade 2 by FNCLCC
  3. id
    OG002
    title
    Histologic Grade 3 by FNCLCC
param Type
COUNT_OF_PARTICIPANTS
population Description
Ineligible patients, as well as patients without histologic grade determined by POG or FNCLCC were excluded. The OM evaluates the degree of agreement of two pathology grading systems applied at diagnosis. The time frame "At diagnosis" reflects the OM.
reporting Status
POSTED
time Frame
At diagnosis
title
Degree of Agreement in Histologic Grade Between Pediatric Oncology Group (POG) and Fédération Nationale Des Centres de Lutte Contre le Cancer (FNCLCC) Pathologic Grading Systems
type
SECONDARY
unit Of Measure
Participants

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice