TriangleNCT00316225 · OUTCOME
Pemetrexed Population Pharmacokinetics: Volume of Distribution
Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.
- Measure
- MEAN
- Unit
- Liters (L)
- Interval / dispersion
- Standard Deviation
- Time frame
- Cycle 1 and Cycle 2: before the end of infusion (approximately 9.5 minutes), 2 hours, 9-10 hours, 24-48 hours, 480-528 hours (20 to 22 days) after start of pemetrexed infusion
What was measured
Volume of distribution is the theoretical size of the compartment necessary to account for total drug amount in the body if it were present throughout the body in the same concentration found in plasma. Volume of distribution is defined as distribution of pemetrexed in the body and is determined by volume of distribution = dose/drug concentration. By knowing dose and measuring concentration of pemetrexed in plasma, volume was calculated. Central volume (V1) was determined by dose/peak serum level of pemetrexed. Peripheral volume (V2) is sum of all tissue spaces outside the central compartment.
Analysis population: Patients who received at least one dose of study drug.
Groups in this outcome
Pemetrexed
Pemetrexed 500 mg/m2 intravenous (IV) every 21 days for 6 cycles
| Group | Source count |
|---|---|
| Pemetrexed | 31 |
Reported measurements
Central Volume of Distribution
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Pemetrexed | 6.61 | 1.32 | Not reported | Not reported | Not reported |
Peripheral Volume of Distribution (V2)
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Pemetrexed | 8.91 | 1.68 | Not reported | Not reported | Not reported |
Peripheral Volume of Distribution (V3)
| Group | Value | Spread | Lower | Upper | Comment |
|---|---|---|---|---|---|
| Pemetrexed | 1.26 | 0 | Not reported | Not reported | Not reported |
Complete source fields
- classes
- categories
- measurements
- group Id
- OG000
- spread
- 1.32
- value
- 6.61
- title
- Central Volume of Distribution
- categories
- measurements
- group Id
- OG000
- spread
- 1.68
- value
- 8.91
- title
- Peripheral Volume of Distribution (V2)
- categories
- measurements
- group Id
- OG000
- spread
- 0
- value
- 1.26
- title
- Peripheral Volume of Distribution (V3)
- denoms
- counts
- group Id
- OG000
- value
- 31
- units
- Participants
- description
- Volume of distribution is the theoretical size of the compartment necessary to account for total drug amount in the body if it were present throughout the body in the same concentration found in plasma. Volume of distribution is defined as distribution of pemetrexed in the body and is determined by volume of distribution = dose/drug concentration. By knowing dose and measuring concentration of pemetrexed in plasma, volume was calculated. Central volume (V1) was determined by dose/peak serum level of pemetrexed. Peripheral volume (V2) is sum of all tissue spaces outside the central compartment.
- dispersion Type
- Standard Deviation
- groups
- description
- Pemetrexed 500 mg/m2 intravenous (IV) every 21 days for 6 cycles
- id
- OG000
- title
- Pemetrexed
- param Type
- MEAN
- population Description
- Patients who received at least one dose of study drug.
- reporting Status
- POSTED
- time Frame
- Cycle 1 and Cycle 2: before the end of infusion (approximately 9.5 minutes), 2 hours, 9-10 hours, 24-48 hours, 480-528 hours (20 to 22 days) after start of pemetrexed infusion
- title
- Pemetrexed Population Pharmacokinetics: Volume of Distribution
- type
- SECONDARY
- unit Of Measure
- Liters (L)
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Preserved source evidence · Not medical advice