{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.32","value":"6.61"}]}],"title":"Central Volume of Distribution"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.68","value":"8.91"}]}],"title":"Peripheral Volume of Distribution (V2)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0","value":"1.26"}]}],"title":"Peripheral Volume of Distribution (V3)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"31"}],"units":"Participants"}],"description":"Volume of distribution is the theoretical size of the compartment necessary to account for total drug amount in the body if it were present throughout the body in the same concentration found in plasma. Volume of distribution is defined as distribution of pemetrexed in the body and is determined by volume of distribution = dose/drug concentration. By knowing dose and measuring concentration of pemetrexed in plasma, volume was calculated. Central volume (V1) was determined by dose/peak serum level of pemetrexed. Peripheral volume (V2) is sum of all tissue spaces outside the central compartment.","dispersionType":"Standard Deviation","groups":[{"description":"Pemetrexed 500 mg/m2 intravenous (IV) every 21 days for 6 cycles","id":"OG000","title":"Pemetrexed"}],"paramType":"MEAN","populationDescription":"Patients who received at least one dose of study drug.","reportingStatus":"POSTED","timeFrame":"Cycle 1 and Cycle 2: before the end of infusion (approximately 9.5 minutes), 2 hours, 9-10 hours, 24-48 hours, 480-528 hours (20 to 22 days) after start of pemetrexed infusion","title":"Pemetrexed Population Pharmacokinetics: Volume of Distribution","type":"SECONDARY","unitOfMeasure":"Liters (L)"}