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NCT00304070 · OUTCOME

Incidence and Type of Germline TP53 Mutations in Non-Brazilian Children and Children From Southern Brazil by Deoxyribonucleic Acid (DNA) Sequencing and Affymetrix Gene Chip Analysis.

Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor · Source last updated 2024-02-28

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
NUMBER
Unit
participants
Interval / dispersion
Not reported
Time frame
At study enrollment

What was measured

The proportion of patients in each subpopulation are compared.This test is dependent on the number of patients from whom blood can be obtained as well as the frequency of the relevant mutation in each group.

Analysis population: The proportion of patients in each subpopulation are compared.This test is dependent on the number of patients from whom blood can be obtained as well as the frequency of the relevant mutation in each group (Number of patients from Brazil: 23. Number of patients not from Brazil: 31)

Groups in this outcome

All Patients

Regardless of Arm/Group assignment, the number of eligible patients from whom blood was obtained as well as the frequency of the relevant mutation in each group.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
All Patients54

Reported measurements

C229R mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
C229R mutation in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients2Not reportedNot reportedNot reportedNot reported
E180K mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
E180K mutation in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
G245C mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
G245C mutation in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
I254T mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
I254T mutation in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
L265Q mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
L265Q mutation in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
P47S mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
P47S mutation in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
Q52fs mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
Q52fs mutation in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
R158L mutation in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
R158L mutation in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
G245S mutation in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
G245S mutation in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
R213P mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
R213P mutation in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
R248L mutation in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
R248L mutation in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
R282W mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
R282W mutation in p53 in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
R283H mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
R283H mutation in p53 in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients31Not reportedNot reportedNot reportedNot reported
R337H mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients20Not reportedNot reportedNot reportedNot reported
R337H mutation in p53 in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
R342X mutation in p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
R342X mutation in p53 in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
T125T c375G>A muation in p53 in Pts from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
T125T c375G>A mutation in p53 in pts not from Braz
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
T125T splice in DBD in pts from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients0Not reportedNot reportedNot reportedNot reported
T125T splice in DBD in pts not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
wild type p53 in Patients from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients1Not reportedNot reportedNot reportedNot reported
wild type p53 in Patients not from Brazil
Values in participants · Interval/dispersion: Not reported
GroupValueSpreadLowerUpperComment
All Patients16Not reportedNot reportedNot reportedNot reported
Complete source fields
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        value
        0
    title
    C229R mutation in p53 in Patients from Brazil
  2. categories
    1. measurements
      1. group Id
        OG000
        value
        2
    title
    C229R mutation in Patients not from Brazil
  3. categories
    1. measurements
      1. group Id
        OG000
        value
        0
    title
    E180K mutation in p53 in Patients from Brazil
  4. categories
    1. measurements
      1. group Id
        OG000
        value
        1
    title
    E180K mutation in Patients not from Brazil
  5. categories
    1. measurements
      1. group Id
        OG000
        value
        0
    title
    G245C mutation in p53 in Patients from Brazil
  6. categories
    1. measurements
      1. group Id
        OG000
        value
        1
    title
    G245C mutation in Patients not from Brazil
  7. categories
    1. measurements
      1. group Id
        OG000
        value
        1
    title
    I254T mutation in p53 in Patients from Brazil
  8. categories
    1. measurements
      1. group Id
        OG000
        value
        0
    title
    I254T mutation in Patients not from Brazil
  9. categories
    1. measurements
      1. group Id
        OG000
        value
        0
    title
    L265Q mutation in p53 in Patients from Brazil
  10. categories
    1. measurements
      1. group Id
        OG000
        value
        1
    title
    L265Q mutation in Patients not from Brazil
  11. categories
    1. measurements
      1. group Id
        OG000
        value
        0
    title
    P47S mutation in p53 in Patients from Brazil
  12. categories
    1. measurements
      1. group Id
        OG000
        value
        1
    title
    P47S mutation in Patients not from Brazil
denoms
  1. counts
    1. group Id
      OG000
      value
      54
    units
    Participants
description
The proportion of patients in each subpopulation are compared.This test is dependent on the number of patients from whom blood can be obtained as well as the frequency of the relevant mutation in each group.
groups
  1. description
    Regardless of Arm/Group assignment, the number of eligible patients from whom blood was obtained as well as the frequency of the relevant mutation in each group.
    id
    OG000
    title
    All Patients
param Type
NUMBER
population Description
The proportion of patients in each subpopulation are compared.This test is dependent on the number of patients from whom blood can be obtained as well as the frequency of the relevant mutation in each group (Number of patients from Brazil: 23. Number of patients not from Brazil: 31)
reporting Status
POSTED
time Frame
At study enrollment
title
Incidence and Type of Germline TP53 Mutations in Non-Brazilian Children and Children From Southern Brazil by Deoxyribonucleic Acid (DNA) Sequencing and Affymetrix Gene Chip Analysis.
type
SECONDARY
unit Of Measure
participants

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice