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NCT00137111 · OUTCOME

Median Difference in CASP1 Gene Expression in Primary Leukemia Cells of Patients in Glucocorticoid-resistant Cells vs Glucocorticoid-sensitive Cells

Therapy for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia · Source last updated 2020-09-11

Results reported by the registry submitting party. Population, time horizon, units and missing values must be read together.

Measure
MEDIAN
Unit
arbitrary units
Interval / dispersion
Inter-Quartile Range
Time frame
Pre-treatment

What was measured

Prednisolone sensitivity was measured in primary leukemia cells from bone marrow collected at diagnosis. Expression of CASP1 was determined by HG-U133A microarray. Values given are gene expression values, and the unit is arbitrary units (AU) defined as scaled fluorescence measured on microarray.

Analysis population: One hundred forty-four (144) patients were evaluable to assess prednisolone sensitivity measured in bone marrow ALL cells and CASP1 expression in RNA by MTT assay.

Groups in this outcome

Total Therapy

Total therapy applies to all eligible patients.

Group identifiers and denominators belong to this outcome only. They may differ in another outcome or in safety reporting.

Analysis denominator · Participants

GroupSource count
Total Therapy144

Reported measurements

Prednisolone-sensitive cells
Values in arbitrary units · Interval/dispersion: Inter-Quartile Range
GroupValueSpreadLowerUpperComment
Total Therapy341.3Not reported202.1430.2Not reported
Prednisolone-resistant cells
Values in arbitrary units · Interval/dispersion: Inter-Quartile Range
GroupValueSpreadLowerUpperComment
Total Therapy447.9Not reported332.2544.9Not reported

Source statistical analyses

Group order, estimate direction, methods and comments are retained. No treatment ranking is inferred.

  1. group Ids
    1. OG000
    non Inferiority Type
    SUPERIORITY_OR_OTHER_LEGACY
    p Value
    0.00000095
    statistical Method
    Wilcoxon (Mann-Whitney)
Complete source fields
analyses
  1. group Ids
    1. OG000
    non Inferiority Type
    SUPERIORITY_OR_OTHER_LEGACY
    p Value
    0.00000095
    statistical Method
    Wilcoxon (Mann-Whitney)
classes
  1. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        202.1
        upper Limit
        430.2
        value
        341.3
    title
    Prednisolone-sensitive cells
  2. categories
    1. measurements
      1. group Id
        OG000
        lower Limit
        332.2
        upper Limit
        544.9
        value
        447.9
    title
    Prednisolone-resistant cells
denoms
  1. counts
    1. group Id
      OG000
      value
      144
    units
    Participants
description
Prednisolone sensitivity was measured in primary leukemia cells from bone marrow collected at diagnosis. Expression of CASP1 was determined by HG-U133A microarray. Values given are gene expression values, and the unit is arbitrary units (AU) defined as scaled fluorescence measured on microarray.
dispersion Type
Inter-Quartile Range
groups
  1. description
    Total therapy applies to all eligible patients.
    id
    OG000
    title
    Total Therapy
param Type
MEDIAN
population Description
One hundred forty-four (144) patients were evaluable to assess prednisolone sensitivity measured in bone marrow ALL cells and CASP1 expression in RNA by MTT assay.
reporting Status
POSTED
time Frame
Pre-treatment
title
Median Difference in CASP1 Gene Expression in Primary Leukemia Cells of Patients in Glucocorticoid-resistant Cells vs Glucocorticoid-sensitive Cells
type
OTHER_PRE_SPECIFIED
unit Of Measure
arbitrary units

Download exact source JSON → · Snapshot ctgov-results-191f4516d4760045304b24a0

Preserved source evidence · Not medical advice