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DISEASE & TREATMENT SETTING

Nasopharyngeal Carcinoma

Source-derived catalogue. This is not a treatment recommendation or a personalised trial match.

Exact scope

Nasopharyngeal Carcinoma

Source population
Not part of this definition
Disease extent
Not part of this definition
Treatment line
Not part of this definition
Stage
Not part of this definition
Resectability
Not part of this definition
Biomarkers, prior therapy and derivation
molecular
    prior therapy
      derivation status
      source-attested
      derivation note
      Derived from NCI topic(s): Nasopharyngeal Carcinoma. Strongest NCIt resolution: exact. Entity-level scope; stage, biomarker and treatment line are not yet part of this definition.
      source wording
      Source null
      7 more-specific settings

      Study evidence for this setting

      11 linked studies · Applicability is a draft source assessment, not a determination of your eligibility.

      NCT00274937 · Registry condition search · Scope: narrower

      Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer

      6 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00492089 · Registry condition search · Scope: narrower

      Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer

      1 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT01256385 · Registry condition search · Scope: narrower

      Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT01344356 · Registry condition search · Scope: narrower

      Stereotactic Body Radiotherapy for Head and Neck Tumors

      4 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT01806675 · Registry condition search · Scope: narrower

      18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy

      5 outcome links · 3 safety-group records · 1 quality-of-life measures

      →

      NCT02123511 · Registry condition search · Scope: narrower

      Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy

      6 outcome links · 2 safety-group records · 3 quality-of-life measures

      →

      NCT02388932 · Registry condition search · Scope: narrower

      Stereotactic Body Radiation Therapy in Treating Patients With High Risk Locally Advanced Head and Neck Cancer

      6 outcome links · 1 safety-group records · 1 quality-of-life measures

      →

      NCT02538510 · Registry condition search · Scope: narrower

      Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery

      4 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT03581786 · Source cited / selected · Scope: narrower

      The Efficacy and Safety Study of TORIPALIMAB INJECTION Combined With Chemotherapy for Nasophapyngeal Cancer

      6 outcome links · 2 safety-group records · 1 quality-of-life measures

      →

      NCT05070247 · Registry condition search · Scope: narrower

      A Study of TAK-500 With or Without Pembrolizumab in Adults With Select Locally Advanced or Metastatic Solid Tumors

      6 outcome links · 14 safety-group records · 0 quality-of-life measures

      →

      NCT05245682 · Registry condition search · Scope: narrower

      Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer

      2 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      Indication-specific source history

      Dated source events, not confirmation of current approval for every use of a drug.

      2025-04-23 · penpulimab-kcqx · approval notification
      release id
      clinical-indications-draft-1
      disease state id
      ds-nasopharyngeal-carcinoma
      event id
      notice-4ef2ac61108c512f
      event date
      2025-04-23
      event kind
      approval-notification
      drug or regimen
      penpulimab-kcqx
      source indication text
      FDA approved penpulimab-kcqx with cisplatin or carboplatin and gemcitabine for the first-line treatment of adults with recurrent or metastatic non-keratinizing nasopharyngeal carcinoma . FDA also approved penpulimab-kcqx as a single agent for adults with metastatic non-keratinizing NPC with disease progression on or after platinum-based chemotherapy and at least one other prior line of therapy.
      match phrase
      nasopharyngeal carcinoma
      match status
      candidate
      status category
      Source null
      has date discrepancy
      0
      source collection
      fda-approval-notice
      source key
      fda-e43d505c8aaeb35e
      source url
      https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-penpulimab-kcqx-non-keratinizing-nasopharyngeal-carcinoma
      curation status
      draft
      reviewed by
      Source null
      reviewed at
      Source null
      created at
      2026-09-10T00:00:00Z
      Original event source →
      Source relationships and population-mapping limitations
      bindings
      1. release id
        clinical-indications-draft-1
        disease state id
        ds-nasopharyngeal-carcinoma
        binding id
        ncit-C3871
        source collection
        ncit-concept
        source key
        C3871
        source excerpt
        Source null
        match status
        exact
        match note
        Source null
        recorded at
        2026-09-10T00:00:00Z
      mappings

        Download this complete draft source relationship record →

        Preserved source evidence · Not medical advice