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DISEASE & TREATMENT SETTING

Myelodysplastic Syndromes

Source-derived catalogue. This is not a treatment recommendation or a personalised trial match.

Exact scope

Myelodysplastic Syndromes

Source population
Not part of this definition
Disease extent
Not part of this definition
Treatment line
Not part of this definition
Stage
Not part of this definition
Resectability
Not part of this definition
Biomarkers, prior therapy and derivation
molecular
    prior therapy
      derivation status
      source-attested
      derivation note
      Derived from NCI topic(s): Myelodysplastic Syndromes. Strongest NCIt resolution: exact. Entity-level scope; stage, biomarker and treatment line are not yet part of this definition.
      source wording
      Source null
      3 more-specific settings

      Study evidence for this setting

      198 linked studies · Applicability is a draft source assessment, not a determination of your eligibility.

      NCT00003270 · Registry condition search · Scope: narrower

      Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer

      2 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00003816 · Registry condition search · Scope: narrower

      Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer

      4 outcome links · 5 safety-group records · 0 quality-of-life measures

      →

      NCT00014495 · Registry condition search · Scope: narrower

      Chemotherapy and Monoclonal Antibody Therapy in Treating Patients With Advanced Myeloid Cancer

      1 outcome links · 4 safety-group records · 0 quality-of-life measures

      →

      NCT00025662 · Registry condition search · Scope: narrower

      Selective T-Cell Depletion to Reduce GVHD (Patients) Receiving Stem Cell Tx to Treat Leukemia, Lymphoma or MDS

      5 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00027560 · Registry condition search · Scope: narrower

      Melphalan, Fludarabine, and Alemtuzumab Followed by Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer

      6 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00040846 · Registry condition search · Scope: narrower

      Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies

      5 outcome links · 6 safety-group records · 0 quality-of-life measures

      →

      NCT00045305 · Registry condition search · Scope: narrower

      Reduced-Intensity Regimen Before Donor Bone Marrow Transplant in Treating Patients With Myelodysplastic Syndromes

      6 outcome links · 1 safety-group records · 1 quality-of-life measures

      →

      NCT00049504 · Registry condition search · Scope: narrower

      Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancer

      3 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00053989 · Registry condition search · Scope: narrower

      NMA Allogeneic Hematopoietic Cell Transplant in Hematologic Cancer/Disorders

      5 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00054327 · Registry condition search · Scope: narrower

      Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer

      5 outcome links · 6 safety-group records · 0 quality-of-life measures

      →

      NCT00067808 · Registry condition search · Scope: narrower

      Study of Three Different Schedules of Low-Dose Decitabine in Myelodysplastic Syndrome (MDS)

      1 outcome links · 3 safety-group records · 0 quality-of-life measures

      →

      NCT00071799 · Source cited / selected · Scope: narrower

      A Survival Study in Patients With High Risk Myelodysplastic Syndromes Comparing Azacitidine Versus Conventional Care

      6 outcome links · 4 safety-group records · 0 quality-of-life measures

      →

      NCT00072475 · Registry condition search · Scope: narrower

      Vatalanib in Treating Patients With Primary or Secondary Myelodysplastic Syndromes

      5 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00074490 · Registry condition search · Scope: narrower

      Donor Stem Cell Transplant With No or Low-Intensity Chemotherapy Using Sirolimus and Treated Immune Cells to Treat Blood and Lymph Cancers

      5 outcome links · 5 safety-group records · 0 quality-of-life measures

      →

      NCT00089011 · Registry condition search · Scope: narrower

      Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT00096122 · Registry condition search · Scope: narrower

      Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia

      1 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00105001 · Registry condition search · Scope: narrower

      Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematolog

      5 outcome links · 3 safety-group records · 0 quality-of-life measures

      →

      NCT00112593 · Registry condition search · Scope: narrower

      Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer

      6 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00113321 · Registry condition search · Scope: narrower

      Low-Dose Decitabine in Myelodysplastic Syndrome Post Azacytidine Failure

      1 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00118352 · Registry condition search · Scope: narrower

      Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by Cyclosporine and Mycophenolate Mofetil in Treating Patients Who Are Undergoing Donor Stem Cell Transplant

      6 outcome links · 3 safety-group records · 0 quality-of-life measures

      →

      Indication-specific source history

      Dated source events, not confirmation of current approval for every use of a drug.

      2025-01-21 · treosulfan with fludarabine · approval notification
      release id
      clinical-indications-draft-1
      disease state id
      ds-myelodysplastic-syndromes
      event id
      notice-b764eaf0506cd66c
      event date
      2025-01-21
      event kind
      approval-notification
      drug or regimen
      treosulfan with fludarabine
      source indication text
      FDA approved treosulfan, an alkylating agent, with fludarabine as a preparative regimen for allogeneic hematopoietic stem cell transplantation in adult and pediatric patients 1 year of age and older with acute myeloid leukemia or myelodysplastic syndrome .
      match phrase
      myelodysplastic syndrome
      match status
      candidate
      status category
      Source null
      has date discrepancy
      0
      source collection
      fda-approval-notice
      source key
      fda-eed3ef224dcd705a
      source url
      https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-treosulfan-fludarabine-preparative-regimen-allohsct-adult-and-pediatric-patients-aml-or
      curation status
      draft
      reviewed by
      Source null
      reviewed at
      Source null
      created at
      2026-09-10T00:00:00Z
      Original event source →
      Source relationships and population-mapping limitations
      bindings
      1. release id
        clinical-indications-draft-1
        disease state id
        ds-myelodysplastic-syndromes
        binding id
        ncit-C3247
        source collection
        ncit-concept
        source key
        C3247
        source excerpt
        Source null
        match status
        exact
        match note
        Source null
        recorded at
        2026-09-10T00:00:00Z
      mappings

        Download this complete draft source relationship record →

        Preserved source evidence · Not medical advice