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← KEYTRUDA QLEX: recurrent Endometrial Carcinoma

NCT03660826 · STUDY IN CONTEXT

Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following

Draft scope assessment: unclear. Attached because the study's own record describes recurrent disease. The study was not selected for this indication by its sponsor, and its eligibility has not been reconciled against this page in full. Found by searching ClinicalTrials.gov for this cancer type, restricted to studies that have posted results to the registry. No FDA notice, FDA label or NCI summary held by this site cites this study. Because the search asked for posted results, studies without posted results were never looked for, so their absence from this page means nothing.

Read the full study record and all posted results →

Linked outcomes

Measures are not ranked. Open each original source section for treatment groups, denominators, units and results.

exploratory · NOT_POSTED

Mutations in Deoxyribonucleic Acid (DNA) Homologous Repair Genes

Source null

→

exploratory · NOT_POSTED

Will assess if markers of angiogenesis in serial plasma samples are associated with response to cediranib alone or in combination with olaparib.

Source null

→

primary · POSTED

Progression-free survival is defined as the time from the date of study enrollment to the investigator-determined date of progression or death due to any cause, whichever occurs first. For individuals who are alive and progression-free, the censored time at risk will be defined as the time from the study enrollment date to the date of the patient's last radiographic disease assessment.

All patients randomized (Intent-to-Treat).

→

secondary · POSTED

Overall survival is defined as the time from the date of study enrollment to the date of death regardless of cause. For those individuals who have no death reported at the time of the analysis, the censored time at risk will be assessed from the date of study enrollment to the date that the patient was last contacted and known to be alive.

All patients randomized (Intent-to-Treat)

→

secondary · POSTED

Objective tumor response was assessed in patients with measurable disease by the site investigator using RECIST v1.1. Patients with complete or partial tumor response were considered to have a response.

All patients who are eligible for response assessment.

→

secondary · POSTED

The number of patients who reported at least a grade 3 adverse event were assessed in those who initiated treatment.

Patients who initiated assigned treatment.

→

Reported safety

Serious events are not the same as severe events. Compare the original safety groups and their at-risk populations.

Open the study safety table →

Quality of life and patient-reported measures

No linked quality-of-life measure is recorded for this setting and study.

Full draft applicability and source-link record
trial
release id
clinical-indications-draft-1
disease state id
ds-endometrial-cancer-keytruda-qlex-1191efca
nct id
NCT03660826
trial label
Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following
applicability
unclear
applicability note
Attached because the study's own record describes recurrent disease. The study was not selected for this indication by its sponsor, and its eligibility has not been reconciled against this page in full.
curation status
draft
reviewed by
Source null
reviewed at
Source null
created at
2026-09-10T00:00:00Z
provenance class
registry-condition-search
discovery note
Found by searching ClinicalTrials.gov for this cancer type, restricted to studies that have posted results to the registry. No FDA notice, FDA label or NCI summary held by this site cites this study. Because the search asked for posted results, studies without posted results were never looked for, so their absence from this page means nothing.
outcome Count
6
harms Count
7
qol Count
0
outcomes
  1. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0004
    source section id
    NCT03660826-om-0004
    source outcome index
    4
    endpoint
    Mutations in Deoxyribonucleic Acid (DNA) Homologous Repair Genes
    endpoint definition
    Mutations in Deoxyribonucleic Acid (DNA) Homologous Repair Genes
    time origin
    Up to 5 years
    analysis role
    exploratory
    reporting status
    NOT_POSTED
    data cutoff
    Source null
    population note
    Source null
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
  2. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0005
    source section id
    NCT03660826-om-0005
    source outcome index
    5
    endpoint
    Markers of Angiogenesis in Serial Plasma Samples
    endpoint definition
    Will assess if markers of angiogenesis in serial plasma samples are associated with response to cediranib alone or in combination with olaparib.
    time origin
    Up to 5 years
    analysis role
    exploratory
    reporting status
    NOT_POSTED
    data cutoff
    Source null
    population note
    Source null
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
  3. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0000
    source section id
    NCT03660826-om-0000
    source outcome index
    0
    endpoint
    Progression-free Survival
    endpoint definition
    Progression-free survival is defined as the time from the date of study enrollment to the investigator-determined date of progression or death due to any cause, whichever occurs first. For individuals who are alive and progression-free, the censored time at risk will be defined as the time from the study enrollment date to the date of the patient's last radiographic disease assessment.
    time origin
    Scans were done every 8 weeks for the first year and then every 12 weeks thereafter until disease progression. Vital status was assessed every 3 months for 2 years and then every 6 months for 3 years (5-years total).
    analysis role
    primary
    reporting status
    POSTED
    data cutoff
    Source null
    population note
    All patients randomized (Intent-to-Treat).
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
  4. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0001
    source section id
    NCT03660826-om-0001
    source outcome index
    1
    endpoint
    Overall Survival
    endpoint definition
    Overall survival is defined as the time from the date of study enrollment to the date of death regardless of cause. For those individuals who have no death reported at the time of the analysis, the censored time at risk will be assessed from the date of study enrollment to the date that the patient was last contacted and known to be alive.
    time origin
    Vital status was assessed every 3 months for 2 years and then every 6 months for 3 years (5-years total).
    analysis role
    secondary
    reporting status
    POSTED
    data cutoff
    Source null
    population note
    All patients randomized (Intent-to-Treat)
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
  5. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0002
    source section id
    NCT03660826-om-0002
    source outcome index
    2
    endpoint
    Objective Tumor Response
    endpoint definition
    Objective tumor response was assessed in patients with measurable disease by the site investigator using RECIST v1.1. Patients with complete or partial tumor response were considered to have a response.
    time origin
    Scans were done every 8 weeks for the first year; then every 12 weeks thereafter until disease progression is confirmed or up to 33 months.
    analysis role
    secondary
    reporting status
    POSTED
    data cutoff
    Source null
    population note
    All patients who are eligible for response assessment.
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
  6. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0003
    source section id
    NCT03660826-om-0003
    source outcome index
    3
    endpoint
    Incidence of Adverse Events
    endpoint definition
    The number of patients who reported at least a grade 3 adverse event were assessed in those who initiated treatment.
    time origin
    Toxicity was assessed every other week for the first 8 weeks of study therapy and every 8 weeks after the completion or termination of study therapy up to 50 months.
    analysis role
    secondary
    reporting status
    POSTED
    data cutoff
    Source null
    population note
    Patients who initiated assigned treatment.
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
arms
  1. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0000
    arm key
    OG000
    arm label
    Arm I (Cediranib maleate_Reference Group 1)
    regimen
    Patients randomized to Cedinarib reference arm during the recruitment period (09/04/2018-06/17/2019). Patients receive Cediranib maleate PO QD. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Cediranib: Given PO Cediranib Maleate: Given PO Computed Tomography: Undergo CT scan Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA
    analyzed count
    40
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0000#groups/OG000
  2. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0000
    arm key
    OG001
    arm label
    Arm II (Olaparib)
    regimen
    Patients receive olaparib PO BID. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Computed Tomography: Undergo CT scan Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA Olaparib: Given PO
    analyzed count
    40
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0000#groups/OG001
  3. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0000
    arm key
    OG002
    arm label
    Arm III (Cediranib Maleate, Olaparib)
    regimen
    Patients receive olaparib PO BID and cediranib maleate PO QD. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Cediranib: Given PO Cediranib Maleate: Given PO Computed Tomography: Undergo CT scan Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA Olaparib: Given PO
    analyzed count
    40
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0000#groups/OG002
  4. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0000
    arm key
    OG003
    arm label
    Arm IV (Olaparib, Capivasertib)
    regimen
    Patients receive olaparib PO BID on days 1-28 and capivasertib PO BID on days 1-4 each week. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Capivasertib: Given PO Computed Tomography: Undergo CT scan Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA Olaparib: Given PO
    analyzed count
    42
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0000#groups/OG003
  5. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0000
    arm key
    OG004
    arm label
    Arm V (Olaparib, Durvalumab)
    regimen
    Patients receive olaparib PO BID on days 1-28 and durvalumab IV on day 1. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Computed Tomography: Undergo CT scan Durvalumab: Given IV Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA Olaparib: Given PO
    analyzed count
    42
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0000#groups/OG004
  6. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0000
    arm key
    OG005
    arm label
    Arm VI (Cediranib Maleate, Durvalumab)
    regimen
    Patients receive cediranib maleate PO QD on days 1-5 each week and durvalumab IV on day 1 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Cediranib Maleate: Given PO Computed Tomography: Undergo CT scan Durvalumab: Given IV Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA
    analyzed count
    43
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0000#groups/OG005
  7. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0000
    arm key
    OG006
    arm label
    Arm VII (Cediranib maleate_Reference Group 2)
    regimen
    Patients randomized to Cedinarib reference arm during the recruitment period (08/16/2021-06/28/2023). Patients receive cediranib maleate PO QD. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Cediranib: Given PO Cediranib Maleate: Given PO Computed Tomography: Undergo CT scan Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA
    analyzed count
    41
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0000#groups/OG006
  8. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0001
    arm key
    OG000
    arm label
    Arm I (Cediranib maleate_Referenc Group 1)
    regimen
    Patients randomized to Cedinarib reference arm during the recruitment period (09/04/2018-06/17/2019). Patients receive Cediranib maleate PO QD. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Cediranib: Given PO Cediranib Maleate: Given PO Computed Tomography: Undergo CT scan Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA
    analyzed count
    40
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0001#groups/OG000
  9. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0001
    arm key
    OG001
    arm label
    Arm II (Olaparib)
    regimen
    Patients receive olaparib PO BID. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Computed Tomography: Undergo CT scan Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA Olaparib: Given PO
    analyzed count
    40
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0001#groups/OG001
  10. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0001
    arm key
    OG002
    arm label
    Arm III (Cediranib Maleate, Olaparib)
    regimen
    Patients receive olaparib PO BID and cediranib maleate PO QD. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Cediranib: Given PO Cediranib Maleate: Given PO Computed Tomography: Undergo CT scan Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA Olaparib: Given PO
    analyzed count
    40
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0001#groups/OG002
  11. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0001
    arm key
    OG003
    arm label
    Arm IV (Olaparib, Capivasertib)
    regimen
    Patients receive olaparib PO BID on days 1-28 and capivasertib PO BID on days 1-4 each week. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Capivasertib: Given PO Computed Tomography: Undergo CT scan Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA Olaparib: Given PO
    analyzed count
    42
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0001#groups/OG003
  12. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    outcome key
    om-0001
    arm key
    OG004
    arm label
    Arm V (Olaparib, Durvalumab)
    regimen
    Patients receive olaparib PO BID on days 1-28 and durvalumab IV on day 1. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity. Additionally, patients undergo blood sample collection, bone marrow aspiration and biopsy, CT, Echo or MUGA on study. Biospecimen Collection: Undergo blood sample collection Bone Marrow Aspirate: Undergo bone marrow aspiration and biopsy Bone Marrow Biopsy: Undergo bone marrow aspiration and biopsy Computed Tomography: Undergo CT scan Durvalumab: Given IV Echocardiography: Undergo Echo Multigated Acquisition Scan: Undergo MUGA Olaparib: Given PO
    analyzed count
    42
    analyzed unit
    Participants
    is comparator
    Source null
    source pointer
    NCT03660826-om-0001#groups/OG004
harms
  1. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    harm key
    EG000
    source section id
    NCT03660826-ae
    event group key
    EG000
    event group label
    Arm I (Cediranib maleate_Reference Group 1)
    serious affected
    17
    serious at risk
    39
    other affected
    38
    other at risk
    39
    frequency threshold
    0
    collection period
    Toxicity was assessed every other week for the first 8 weeks of study therapy and every 8 weeks after the completion or termination of study therapy. Median follow-up was 22 months.
    event definition
    Patients randomized were included for the all-cause mortality summary. Patients randomized and also initiated treatment were included for the AE/SAE summary.
    undenominated note
    Source null
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
  2. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    harm key
    EG001
    source section id
    NCT03660826-ae
    event group key
    EG001
    event group label
    Arm II (Olaparib)
    serious affected
    12
    serious at risk
    40
    other affected
    40
    other at risk
    40
    frequency threshold
    0
    collection period
    Toxicity was assessed every other week for the first 8 weeks of study therapy and every 8 weeks after the completion or termination of study therapy. Median follow-up was 22 months.
    event definition
    Patients randomized were included for the all-cause mortality summary. Patients randomized and also initiated treatment were included for the AE/SAE summary.
    undenominated note
    Source null
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
  3. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    harm key
    EG002
    source section id
    NCT03660826-ae
    event group key
    EG002
    event group label
    Arm III (Cediranib Maleate, Olaparib)
    serious affected
    19
    serious at risk
    39
    other affected
    39
    other at risk
    39
    frequency threshold
    0
    collection period
    Toxicity was assessed every other week for the first 8 weeks of study therapy and every 8 weeks after the completion or termination of study therapy. Median follow-up was 22 months.
    event definition
    Patients randomized were included for the all-cause mortality summary. Patients randomized and also initiated treatment were included for the AE/SAE summary.
    undenominated note
    Source null
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
  4. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    harm key
    EG003
    source section id
    NCT03660826-ae
    event group key
    EG003
    event group label
    Arm IV (Olaparib, Capivasertib)
    serious affected
    11
    serious at risk
    42
    other affected
    41
    other at risk
    42
    frequency threshold
    0
    collection period
    Toxicity was assessed every other week for the first 8 weeks of study therapy and every 8 weeks after the completion or termination of study therapy. Median follow-up was 22 months.
    event definition
    Patients randomized were included for the all-cause mortality summary. Patients randomized and also initiated treatment were included for the AE/SAE summary.
    undenominated note
    Source null
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
  5. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    harm key
    EG004
    source section id
    NCT03660826-ae
    event group key
    EG004
    event group label
    Arm V (Olaparib, Durvalumab)
    serious affected
    16
    serious at risk
    42
    other affected
    42
    other at risk
    42
    frequency threshold
    0
    collection period
    Toxicity was assessed every other week for the first 8 weeks of study therapy and every 8 weeks after the completion or termination of study therapy. Median follow-up was 22 months.
    event definition
    Patients randomized were included for the all-cause mortality summary. Patients randomized and also initiated treatment were included for the AE/SAE summary.
    undenominated note
    Source null
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
  6. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    harm key
    EG005
    source section id
    NCT03660826-ae
    event group key
    EG005
    event group label
    Arm VI (Cediranib Maleate, Durvalumab)
    serious affected
    13
    serious at risk
    42
    other affected
    40
    other at risk
    42
    frequency threshold
    0
    collection period
    Toxicity was assessed every other week for the first 8 weeks of study therapy and every 8 weeks after the completion or termination of study therapy. Median follow-up was 22 months.
    event definition
    Patients randomized were included for the all-cause mortality summary. Patients randomized and also initiated treatment were included for the AE/SAE summary.
    undenominated note
    Source null
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
  7. release id
    clinical-indications-draft-1
    disease state id
    ds-endometrial-cancer-keytruda-qlex-1191efca
    nct id
    NCT03660826
    harm key
    EG006
    source section id
    NCT03660826-ae
    event group key
    EG006
    event group label
    Arm VII (Cediranib maleate_Reference Group 2)
    serious affected
    19
    serious at risk
    37
    other affected
    37
    other at risk
    37
    frequency threshold
    0
    collection period
    Toxicity was assessed every other week for the first 8 weeks of study therapy and every 8 weeks after the completion or termination of study therapy. Median follow-up was 22 months.
    event definition
    Patients randomized were included for the all-cause mortality summary. Patients randomized and also initiated treatment were included for the AE/SAE summary.
    undenominated note
    Source null
    curation status
    draft
    reviewed by
    Source null
    reviewed at
    Source null
    created at
    2026-09-10T00:00:00Z
quality of life
    setting source links

      Preserved source evidence · Not medical advice