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DISEASE & TREATMENT SETTING

KEYTRUDA QLEX: recurrent Endometrial Carcinoma

Source-derived catalogue. This is not a treatment recommendation or a personalised trial match.

Exact scope

1.15 Endometrial Carcinoma KEYTRUDA QLEX, in combination with carboplatin and paclitaxel, followed by KEYTRUDA QLEX as a single agent, is indicated for the treatment of adult patients with primary advanced or recurrent endometrial carcinoma.

Broader topic: Endometrial Cancer

Source population
Not part of this definition
Disease extent
recurrent
Treatment line
Not part of this definition
Stage
Not part of this definition
Resectability
Not part of this definition
Biomarkers, prior therapy and derivation
molecular
    prior therapy
      derivation status
      source-attested
      derivation note
      Scoped from the FDA approved indication for KEYTRUDA QLEX (product label). Only dimensions stated in that wording are part of this definition.
      source wording
      1.15 Endometrial Carcinoma KEYTRUDA QLEX, in combination with carboplatin and paclitaxel, followed by KEYTRUDA QLEX as a single agent, is indicated for the treatment of adult patients with primary advanced or recurrent endometrial carcinoma.

      Study evidence for this setting

      15 linked studies · Applicability is a draft source assessment, not a determination of your eligibility.

      NCT00474994 · Registry condition search · Scope: unclear

      Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas

      1 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT00545792 · Registry condition search · Scope: unclear

      Safety Study Of Avastin And Pelvic Radiation In Women With Recurrent Gynecological Cancers

      2 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT01010126 · Registry condition search · Scope: unclear

      Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer

      6 outcome links · 6 safety-group records · 0 quality-of-life measures

      →

      NCT01079832 · Registry condition search · Scope: unclear

      Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies

      5 outcome links · 1 safety-group records · 1 quality-of-life measures

      →

      NCT01210222 · Registry condition search · Scope: unclear

      Trebananib in Treating Patients With Persistent or Recurrent Endometrial Cancer

      5 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT01797523 · Source cited / selected · Scope: unclear

      A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma

      4 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT02065687 · Source cited / selected · Scope: unclear

      Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer

      6 outcome links · 2 safety-group records · 1 quality-of-life measures

      →

      NCT02142803 · Registry condition search · Scope: unclear

      TORC1/2 Inhibitor MLN0128 and Bevacizumab in Treating Patients With Recurrent Glioblastoma or Advanced Solid Tumors

      6 outcome links · 3 safety-group records · 1 quality-of-life measures

      →

      NCT02228681 · Source cited / selected · Scope: unclear

      Everolimus and Letrozole or Hormonal Therapy to Treat Endometrial Cancer

      6 outcome links · 2 safety-group records · 0 quality-of-life measures

      →

      NCT02549989 · Source cited / selected · Scope: unclear

      Study of LY3023414 for the Treatment of Recurrent or Persistent Endometrial Cancer

      5 outcome links · 1 safety-group records · 0 quality-of-life measures

      →

      NCT03367741 · Registry condition search · Scope: unclear

      Cabozantinib S-malate and Nivolumab in Treating Patients With Advanced, Recurrent, or Metastatic Endometrial Cancer

      5 outcome links · 3 safety-group records · 0 quality-of-life measures

      →

      NCT03395080 · Registry condition search · Scope: unclear

      A Study of DKN-01 as a Monotherapy or in Combination With Paclitaxel in Patients With Recurrent Epithelial Endometrial or Epithelial Ovarian Cancer or Carcinosarcoma

      6 outcome links · 8 safety-group records · 0 quality-of-life measures

      →

      NCT03660826 · Registry condition search · Scope: unclear

      Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following

      6 outcome links · 7 safety-group records · 0 quality-of-life measures

      →

      NCT03914612 · Source cited / selected · Scope: unclear

      Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer

      6 outcome links · 4 safety-group records · 2 quality-of-life measures

      →

      NCT04269200 · Source cited / selected · Scope: unclear

      Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer

      6 outcome links · 6 safety-group records · 2 quality-of-life measures

      →
      Source relationships and population-mapping limitations
      bindings
        mappings

          Download this complete draft source relationship record →

          Preserved source evidence · Not medical advice