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DISEASE & TREATMENT SETTING

Tivdak: metastatic cervical cancer after prior therapy

Source-derived catalogue. This is not a treatment recommendation or a personalised trial match.

Exact scope

Treatment of adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy

Broader topic: Cervical Cancer

Source population
Not part of this definition
Disease extent
metastatic
Treatment line
Not part of this definition
Stage
Not part of this definition
Resectability
Not part of this definition
Biomarkers, prior therapy and derivation
molecular
    prior therapy
    1. class
      after chemotherapy
      status
      required
    derivation status
    source-attested
    derivation note
    Scoped from the FDA approved indication for Tivdak (tisotumab vedotin-tftv) (accelerated-approval table). Only dimensions stated in that wording are part of this definition.
    source wording
    Treatment of adult patients with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy

    Study evidence for this setting

    15 linked studies · Applicability is a draft source assessment, not a determination of your eligibility.

    NCT00577317 · Registry condition search · Scope: unclear

    Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cance

    6 outcome links · 2 safety-group records · 1 quality-of-life measures

    →

    NCT01079832 · Registry condition search · Scope: unclear

    Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies

    5 outcome links · 1 safety-group records · 1 quality-of-life measures

    →

    NCT01583686 · Registry condition search · Scope: unclear

    CAR T Cell Receptor Immunotherapy Targeting Mesothelin for Patients With Metastatic Cancer

    2 outcome links · 5 safety-group records · 0 quality-of-life measures

    →

    NCT01585428 · Registry condition search · Scope: unclear

    Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers

    2 outcome links · 2 safety-group records · 0 quality-of-life measures

    →

    NCT01631552 · Source cited / selected · Scope: unclear

    Study of Sacituzumab Govitecan-hziy (IMMU-132) in Adults With Epithelial Cancer

    6 outcome links · 1 safety-group records · 0 quality-of-life measures

    →

    NCT02001623 · Source cited / selected · Scope: unclear

    Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors

    6 outcome links · 15 safety-group records · 0 quality-of-life measures

    →

    NCT02466971 · Registry condition search · Scope: unclear

    Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers

    6 outcome links · 2 safety-group records · 0 quality-of-life measures

    →

    NCT02552121 · Source cited / selected · Scope: unclear

    Tisotumab Vedotin (HuMax®-TF-ADC) Safety Study in Patients With Solid Tumors

    6 outcome links · 8 safety-group records · 0 quality-of-life measures

    →

    NCT03260023 · Registry condition search · Scope: unclear

    Phase Ib/II of TG4001 and Avelumab in HPV16 Positive R/M Cancers

    6 outcome links · 7 safety-group records · 0 quality-of-life measures

    →

    NCT03438396 · Source cited / selected · Scope: unclear

    A Trial of Tisotumab Vedotin in Cervical Cancer

    6 outcome links · 1 safety-group records · 0 quality-of-life measures

    →

    NCT03439085 · Registry condition search · Scope: unclear

    DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated C

    4 outcome links · 1 safety-group records · 0 quality-of-life measures

    →

    NCT03635567 · Source cited / selected · Scope: unclear

    Efficacy and Safety Study of First-line Treatment With Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Women With Persistent, Recurrent, or Metastatic

    6 outcome links · 3 safety-group records · 1 quality-of-life measures

    →

    NCT04234113 · Registry condition search · Scope: unclear

    Study of Nanrilkefusp Alfa Alone and With Pembrolizumab in Adult Patients With Advanced/Metastatic Solid Tumors

    6 outcome links · 17 safety-group records · 0 quality-of-life measures

    →

    NCT04697628 · Source cited / selected · Scope: unclear

    Tisotumab Vedotin vs Chemotherapy in Recurrent or Metastatic Cervical Cancer

    6 outcome links · 2 safety-group records · 4 quality-of-life measures

    →

    NCT05012397 · Registry condition search · Scope: unclear

    Milademetan in Advanced/Metastatic Solid Tumors

    5 outcome links · 1 safety-group records · 0 quality-of-life measures

    →
    Source relationships and population-mapping limitations
    bindings
      mappings

        Download this complete draft source relationship record →

        Preserved source evidence · Not medical advice