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UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions

  • PhasePhase 2
  • StatusRecruiting
  • Planned enrollment90 people
  • Recruiting US sites1
  • SponsorJona Hattangadi-Gluth
  • RegistryNCT04343157

Recruitment re-checked on ClinicalTrials.gov Oct 30, 2026. Public record; not medical advice.

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions: a one-minute explainerNCT043431571 min

Eligibility

Who can join

The film gives the main points. The full list below is copied from the registry; the study team makes the final decision.

  • Age18 Years to no maximum
  • SexAll
  • Healthy volunteersNo

You may be able to join if

  • Patients 18 years or older
  • Eligible for intracranial SRS: Limited brain metastases targets geometrically feasible for SRS (intact or resected tumor bed), meningioma, or cerebral AVM
  • Eastern cooperative Oncology Group (ECOG) performance status 0-2 (score of 0, no symptoms; 1, mild symptoms; 2, symptomatic, <50% in bed during the day)
  • Ability to answer questions and follow commands via neurocognitive testing
  • Estimated life expectancy greater than 6 months
  • Pathologic confirmation of extracerebral tumor site (eg, lung, breast, prostate) from either the primary site or a metastatic lesion if brain metastasis
  • Willingness/Ability to undergo brain MRI scans
  • Able to give informed consent

You cannot join if

  • Pregnant or nursing women
  • Women of childbearing potential unwilling to use adequate contraception
  • Inability to complete a magnetic resonance imaging scan with contrast
  • Tumor directly invading the critical area to be spared (for example a patient with tumor invading a critical white matter tract; ineligible for cognitive-sparing)
  • Planned chemotherapy during SRS (on the day of SRS)
  • Previous whole brain radiation therapy
  • Leptomeningeal metastases (ineligible for SRS)
  • Metastases from primary germ cell tumor, small cell carcinoma, or primary CNS lymphoma (ineligible for SRS)

The treatment

How it is intended to work

This is how the treatment is meant to work. Whether it helps, and how safe it is, is what this trial is testing.

Treatments listed in the registry

  • Cognitive Sparing Brain Stereotactic Radiosurgery (SRS) (Radiation): In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function during SRS for intracranial lesions

The study

Treatment groups

Na · Single Group · masking: None

Image-guided cognitive sparing brain SRS (Experimental)

This is a single arm phase II study where enrolled subjects will receive intracranial SRS will performed identically to standard of care, except for implementing additional imaging techniques and software for additional regional avoidance for cognitive sparing (specifically sparing white matter and the bilateral hippocampus)

What it involves

Procedures

As the registry describes them. Requirements to join, such as a tissue sample, are in the eligibility list above even when on-study procedures are optional. Ask the study team which steps apply to you.

  • MRI: Part of the study plan

Goals

What the study measures

Main goals

  • Change in Verbal Memory from baseline to 3 months after SRS (Change from Baseline (pre-treatment) to 3 months post treatment)
  • Change in Executive Functioning from baseline to 3 months after SRS (Change from Baseline (pre-treatment) to 3 months post treatment)
  • Change in Attention/Processing Speed from baseline to 3 months after SRS (Change from Baseline (pre-treatment) to 3 months post treatment)
  • Change in Language functioning from baseline to 3 months after SRS (Change from Baseline (pre-treatment) to 3 months post treatment)

Other goals

  • Longitudinal changes in imaging biomarker fractional anisotropy (FA) from DTI imaging
  • Longitudinal changes in imaging biomarker mean diffusivity (MD) from DTI imaging
  • Longitudinal changes in imaging biomarker volume from volumetric MR imaging

Planned enrollment: 90 (estimated).

Where

Recruiting US sites

  • Moores Cancer Center, San Diego, California

Site status as of Oct 30, 2026. Check the live record before contacting a site.

Background research

Papers linked by the registry

These papers are listed in the registry record. Unless a paper is marked as about this trial, it is background research on the treatment or disease, not results from this study.

Sources

Where this comes from

Registry record reviewed as fetched Oct 30, 2026, last updated by the sponsor Sep 7, 2026. Public record; not medical advice.

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