Radiation Therapy Approaches for People With Prostate Cancer

The film gives the main points. The full list below is copied from the registry; the study team makes the final decision.

• AgeNo minimum to no maximum
• SexAll
• Healthy volunteersNo

You may be able to join if

• Non-metastatic prostate cancer.
• Classified as unfavorable intermediate-, high-, or very high-risk prostate cancer according to NCCN risk stratification guidelines. (Note: cT3a or T3b by MRI or PSMA PET allowed)
• Considered by the treating radiation oncologist as a suitable candidate for both HDR brachytherapy boost and SBRT

You cannot join if

• None

This is how the treatment is meant to work. Whether it helps, and how safe it is, is what this trial is testing.

Treatments listed in the registry

• Standard of Care HDR Brachytherapy (Radiation): HDR Brachytherapy
• SBRT (Radiation): SBRT alone

Randomized · Parallel · masking: None

As the registry describes them. Requirements to join, such as a tissue sample, are in the eligibility list above even when on-study procedures are optional. Ask the study team which steps apply to you.

• radiation: Part of the study plan

Main goals

• Change in International Prostate Symptom Score / IPSS at 3 months (3 months)

Planned enrollment: 126 (estimated).

• Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey
• Memorial Sloan Kettering at Monmouth (Limited Protocol Activities), Middletown, New Jersey
• Memorial Sloan Kettering at Bergen (Limited Protocol Activities), Montvale, New Jersey
• Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities), Commack, New York
• Memorial Sloan Kettering at Westchester (Limited Protocol Activities), Harrison, New York
• Memorial Sloan Kettering Cancer Center (All Protocol Activites), New York, New York
• Memorial Sloan Kettering at Nassau (Limited Protocol Activities), Uniondale, New York

Site status as of Oct 30, 2026. Check the live record before contacting a site.

• ClinicalTrials.gov NCT07751159

Registry record reviewed as fetched Oct 30, 2026, last updated by the sponsor Aug 11, 2026. Public record; not medical advice.