PROton Therapy for Post Surgical Treatment of GYNecologic Cancer

The film gives the main points. The full list below is copied from the registry; the study team makes the final decision.

• Age18 Years to no maximum
• SexFemale
• Healthy volunteersNo

You may be able to join if

• Histologically confirmed cervical or endometrial cancer
• Indication for adjuvant whole pelvic radiation therapy, with or without systemic therapy
• Age of 18 years or older
• Written informed consent
• ECOG of 0-2 within 3 months of enrolling

You cannot join if

• Prior course of pelvic radiation
• Metastatic disease outside of the pelvis
• Active inflammatory bowel disease
• Incapacity to provide informed consent

This is how the treatment is meant to work. Whether it helps, and how safe it is, is what this trial is testing.

Treatments listed in the registry

• Whole Pelvis (WP) Pencil Beam Scanning Proton Radiation (PBS PRT) (Radiation): The study intervention is Whole Pelvis (WP) Pencil Beam Scanning Proton Radiation (PBS PRT) as part of the definitive treatment of gynecologic cancers in the post-hysterectomy, adjuvant setting. Patients will be treated with doses of 45 or 50.4 Gy in 1.8 Gy daily fractions. The volume treated will include the whole pelvis according to Radiation Therapy Oncology Group post-hysterectomy pelvis guidelines.

Na · Single Group · masking: None

As the registry describes them. Requirements to join, such as a tissue sample, are in the eligibility list above even when on-study procedures are optional. Ask the study team which steps apply to you.

• radiation: Part of the study plan

Main goals

• Acute clinician-reported gastrointestinal (GI) toxicity. (Up to 6 months after end of treatment at follow up visits)

Other goals

• Acute clinician-reported genitourinary (GU) toxicity.
• Acute patient-reported gastrointestinal (GI) and genitourinary (GU) toxicity and quality of life.
• Loco-regional recurrence free survival, disease free survival, and overall survival.

Planned enrollment: 25 (estimated).

• Virtua Health, Voorhees Township, New Jersey
• Lancaster General Health - Ann B. Barshinger Cancer Institute, Lancaster, Pennsylvania
• University of Pennsylvania, Philadelphia, Pennsylvania

Site status as of Oct 30, 2026. Check the live record before contacting a site.

• ClinicalTrials.gov NCT05758688

Registry record reviewed as fetched Oct 30, 2026, last updated by the sponsor Sep 16, 2026. Public record; not medical advice.