IIT2023-09-Chung-UpfrontTAD: Upfront TAD/SNB in Patients With Breast Cancer With Nodal Metastases

The film gives the main points. The full list below is copied from the registry; the study team makes the final decision.

• Age45 Years to no maximum
• SexFemale
• Healthy volunteersNo

You may be able to join if

• Women age ≥ 45
• Clinical T1-2N0 ER+ invasive breast cancer
• US detected biopsy proven axillary nodal disease
• Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.

You cannot join if

• Palpable nodes on physical exam
• Her2+ or ER- invasive breast cancer
• Extranodal extension > 3 mm on nodal biopsy
• More than 2 suspicious nodes on preoperative imaging

This is how the treatment is meant to work. Whether it helps, and how safe it is, is what this trial is testing.

Treatments listed in the registry

• Breast Surgery (BCS or mastectomy) with TAD/SNB (Procedure): Breast surgery (BCS or mastectomy) with TAD/SNB & Adjuvant Radiation therapy
• Adjuvant Radiation Therapy (Radiation): Breast surgery (BCS or mastectomy) with TAD/SNB & Adjuvant Radiation therapy

Na · Single Group · masking: None

As the registry describes them. Requirements to join, such as a tissue sample, are in the eligibility list above even when on-study procedures are optional. Ask the study team which steps apply to you.

• surgery: Part of the study plan
• radiation: Part of the study plan

Main goals

• Regional recurrence rate (5 Years)

Other goals

• Local recurrence rate
• Disease-free survival (DFS)
• Breast cancer specific survival (BCSS) rate
• Overall survival (OS)

Planned enrollment: 45 (estimated).

• Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles, California
• CS Cancer at Huntington Cancer Center, Pasadena, California
• CS Cancer at Valley Oncology Medical Group, Tarzana, California

Site status as of Oct 30, 2026. Check the live record before contacting a site.

• ClinicalTrials.gov NCT06092892

Registry record reviewed as fetched Oct 30, 2026, last updated by the sponsor Aug 9, 2026. Public record; not medical advice.