Fluorescence-Guided Surgical Resection for Reducing Unexpected Positive Margins in Patients With Sarcoma, SarcoSIGHT Trial

The film gives the main points. The full list below is copied from the registry; the study team makes the final decision.

• AgeNo minimum to no maximum
• SexAll
• Healthy volunteersNo

You may be able to join if

• Documented written informed consent of the participant
• Histologically confirmed diagnosis of intermediate to high grade sarcoma
• All ages
• Amenable to surgical resection as a part of curative intent for the patient
• Willingness to:
• Respond to surveys during the trial
• Permit medical record/ clinical laboratory result review

You cannot join if

• Due for surgery with palliative intent
• Recurrent tumors
• Intracranial, retroperitoneal, and visceral anatomical locations
• A woman of childbearing potential who is currently pregnant (as confirmed by urine pregnancy test)
• A woman who are currently breastfeeding
• Known allergies to ICG, iodine, iodine dyes or shellfish
• Unable to provide written and informed consent
• Patients with hyper-thyroidism or autonomic thyroid adenomas
• Premature infants/neonates with exchange transfusion indication due to hyperbilirubinemia

This is how the treatment is meant to work. Whether it helps, and how safe it is, is what this trial is testing.

Treatments listed in the registry

• Electronic Health Record Review (Other): Ancillary studies
• Fluorescence Imaging (Procedure): Undergo fluorescence imaging
• Fluorescence-Guided Surgery (Procedure): Undergo FGS
• Indocyanine Green (Drug): Given IV
• Questionnaire Administration (Other): Ancillary studies
• Resection (Procedure): Undergo surgical resection

Randomized · Parallel · masking: Single

As the registry describes them. Requirements to join, such as a tissue sample, are in the eligibility list above even when on-study procedures are optional. Ask the study team which steps apply to you.

• questionnaires: Part of the study plan
• surgery: Part of the study plan

Main goals

• Unexpected positive margin (UPM) rate (At 6 months post-surgery)

Other goals

• Intraoperative complications
• Postoperative complications
• Length of index operation
• Length of inpatient stay
• Recurrence
• Therapies
• Overall survival
• Quality of life
• Recovery following resection
• Surgical impact and decision making

Planned enrollment: 22 (estimated).

• City of Hope Medical Center, Duarte, California

Site status as of Oct 30, 2026. Check the live record before contacting a site.

• ClinicalTrials.gov NCT07650656

Registry record reviewed as fetched Oct 30, 2026, last updated by the sponsor Oct 15, 2026. Public record; not medical advice.