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Treatment of stage II Wilms tumor
Source: Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: April 15, 2025 · Captured 2026-09-09.
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Context: Wilms Tumor / Treatment of Wilms Tumor
Table 5 provides an overview of the standard treatment options and survival data for patients with stage II Wilms tumor, based on published results.
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| Histology | 4-Year RFS or EFS | 4-Year OS | Treatmentb |
|---|---|---|---|
| DA = diffuse anaplastic; EFS = event-free survival; FA = focal anaplastic; FH = favorable histology; LOH = loss of heterozygosity; OS = overall survival; RFS = relapse-free survival; XRT = radiation therapy. | |||
| aSource: Grundy et al.,[110] Dome et al.,[183] Dix et al.,[264] Daw et al.,[267] and Armstrong et al.[276] | |||
| bFor chemotherapy regimen descriptions, see Table 2. | |||
| FH | 86% RFS | 98% | Nephrectomy + lymph node sampling followed by regimen EE-4A |
| FH LOH 1p/16q (n = 24) | 83% EFS | 100% | Nephrectomy + lymph node sampling followed by regimen DD-4A |
| FA | 100% EFS | 100% (n = 2) | Nephrectomy + lymph node sampling followed by abdominal XRT and regimen DD-4A |
| DA | 84% EFS | 84% (n = 19) | Nephrectomy + lymph node sampling followed by abdominal XRT and regimen UH1 |
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