Treatment Options for Stage IVB Vulvar Cancer

There is no standard treatment approach in the management of stage IVB vulvar cancer.

Local therapy must be individualized depending on the extent of local and metastatic disease.

There is no standard chemotherapy for metastatic disease, and reports describing the use of this modality are anecdotal.[1] However, by largely extrapolating from regimens used for anal or cervical cancer, chemotherapy has been studied. Regimens have included various combinations of fluorouracil, cisplatin, mitomycin, or bleomycin.[1-3] Given the advanced age and comorbidity of many patients with advanced or recurrent vulvar cancer, patient tolerance is a major consideration in the use of these agents.