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Treatment Options for Stage I Adenocarcinoma of the Vagina
Source: Vaginal Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: April 3, 2025 · Captured 2026-09-09.
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Context: Treatment of Stage I Vaginal Cancer
Treatment options for stage I adenocarcinoma of the vagina include:
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Surgery.
Surgery.
Total radical vaginectomy and hysterectomy with lymph node dissection are indicated because the tumor spreads subepithelially.
Surgery.
The deep pelvic lymph nodes are dissected if the lesion invades the upper vagina, and the inguinal lymph nodes are removed if the lesion originates in the lower vagina.
Surgery.
Construction of a neovagina may be performed if feasible and if desired by the patient.[6]
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Surgery.
In cases with close or positive surgical margins, adjuvant radiation therapy is often given.[6,7]
Radiation therapy.
Radiation therapy.
Intracavitary and interstitial radiation are administered to a dose of at least 75 Gy to the primary tumor.[1]
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Radiation therapy.
For lesions in the lower third of the vagina, elective radiation therapy of 45 Gy to 50 Gy is given to the pelvic and/or inguinal lymph nodes.[1,9]
Combined local therapy in selected cases, which may include wide local excision, lymph node sampling, and interstitial therapy.[10]
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Preserved source evidence · Not medical advice