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Axillary Lymph Node(s) With Adenocarcinoma Histology (Breast Paradigm)
Source: Cancer of Unknown Primary (CUP) Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 7, 2025 · Captured 2026-09-09.
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Context: Treatment of Newly Diagnosed Favorable Cancer of Unknown Primary
Less than 1% of female patients present with histological breast cancer in an axillary lymph node with an occult primary even after MRI of the breast.[9] Initial pathological studies should include estrogen-receptor, progesterone-receptor, and human epidermal growth factor (HER2) status, with further molecular and genetic studies done subsequently. Surgery, radiation therapy, neoadjuvant or adjuvant chemotherapy, and/or hormonal therapy are given according to guidelines for conventional breast cancer.[10-13]
For more information, see Breast Cancer Treatment.
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