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← Cancer of Unknown Primary (CUP)

FOR PATIENTS · SOURCE READING

Treatment of Recurrent Carcinoma of Unknown Primary

Source: Carcinoma of Unknown Primary Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: December 17, 2021 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.

For information about the treatments listed below, see the Treatment Option Overview section.

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Treatment for recurrent carcinoma of unknown primary is usually within a clinical trial. Treatment depends on the following:

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The type of cancer.

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How the cancer was treated before.

Where the cancer has come back in the body.

The condition and wishes of the patient.

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Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

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Preserved source evidence · Independent clinical review pending · Not medical advice