TriangleHEALTH PROFESSIONAL · SOURCE READING
Cervical Lymph Node(s) With Squamous Cell Histology (Head and Neck Paradigm)
Source: Cancer of Unknown Primary (CUP) Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 7, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.
Context: Treatment of Newly Diagnosed Favorable Cancer of Unknown Primary
PET-CT, MRI, and pan-endoscopy for biopsies and bilateral tonsillectomies are performed when squamous cell carcinoma is identified in cervical lymph nodes (not supraclavicular) in patients with CUP.[5]
Source links and citations
Transoral robotic surgery may replace pan-endoscopy in the search for a primary site in the head and neck region.[6] Pathological studies should include testing for p16 expression to assess human papillomavirus status, Epstein-Barr virus status, and PD-L1 expression.[7]
For more information, see Metastatic Squamous Neck Cancer with Occult Primary Treatment.
Source links and citations
Publication references
Read the original reference and check its publication notices.
Preserved source evidence · Not medical advice