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← Cancer of Unknown Primary (CUP)

FOR PATIENTS · SOURCE READING

Multiple Involvement

Source: Carcinoma of Unknown Primary Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: December 17, 2021 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.

Context: Treatment of Newly Diagnosed Carcinoma of Unknown Primary

For information about the treatments listed below, see the Treatment Option Overview section.

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There is no standard treatment for carcinoma of unknown primary that is found in several different areas of the body. Treatment may include the following:

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Hormone therapy.

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Internal radiation therapy.

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Chemotherapy with one or more anticancer drugs.

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A clinical trial.

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Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

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Preserved source evidence · Independent clinical review pending · Not medical advice