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Inguinal Lymph Nodes With Squamous Cell Histology (Genitourinary or Anorectal Source)
Source: Cancer of Unknown Primary (CUP) Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 7, 2025 · Captured 2026-09-09.
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Context: Treatment of Newly Diagnosed Favorable Cancer of Unknown Primary
Squamous cell carcinoma in an inguinal or iliac site is usually associated with a genital or anorectal primary. Examinations should focus on the vulva, vagina, and cervix in women, and the penis in men. In both sexes, the anorectal area should be examined, and any suspicious areas should be biopsied. Anecdotal cures have been reported in a few cases of isolated inguinal or iliac sites with an occult primary after staging studies.[8]
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