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← Thyroid Cancer

HEALTH PROFESSIONAL · SOURCE READING

Total thyroidectomy

Source: Thyroid Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: May 9, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.

Context: Papillary and Follicular Thyroid Cancer / Treatment Options for Papillary and Follicular Thyroid Cancer / Localized/regional papillary and follicular thyroid cancer / Treatment options for localized/regional papillary and follicular thyroid cancer

Total thyroidectomy is often used because of the high incidence of multicentric involvement of both lobes of the gland and the possibility of dedifferentiation of any residual tumor to the anaplastic cell type.

Evidence (total thyroidectomy):

An analysis of the National Cancer Data Base (NCDB) registry identified 52,173 patients who underwent surgery for papillary thyroid cancer. Of these individuals, 43,227 (82.9%) underwent total thyroidectomy, and 8,946 (17.1%) underwent lobectomy.[9][Level of evidence C1]

Source links and citations

An analysis of the National Cancer Data Base (NCDB) registry identified 52,173 patients who underwent surgery for papillary thyroid cancer. Of these individuals, 43,227 (82.9%) underwent total thyroidectomy, and 8,946 (17.1%) underwent lobectomy.[9][Level of evidence C1]

For a papillary thyroid cancer tumor that measured less than 1 cm, the extent of surgery did not impact recurrence (P = .24) or survival (P = .83).

An analysis of the National Cancer Data Base (NCDB) registry identified 52,173 patients who underwent surgery for papillary thyroid cancer. Of these individuals, 43,227 (82.9%) underwent total thyroidectomy, and 8,946 (17.1%) underwent lobectomy.[9][Level of evidence C1]

For tumors that measured 1 cm or larger, lobectomy resulted in higher risk of recurrence (P = .04) and death (P = .009).

An analysis of the National Cancer Data Base (NCDB) registry identified 52,173 patients who underwent surgery for papillary thyroid cancer. Of these individuals, 43,227 (82.9%) underwent total thyroidectomy, and 8,946 (17.1%) underwent lobectomy.[9][Level of evidence C1]

To minimize the influence of larger tumors, 1-cm to 2-cm lesions were examined separately. Lobectomy resulted in a higher risk of recurrence (P = .04) and death (P = .04).

An analysis of the National Cancer Data Base (NCDB) registry identified 52,173 patients who underwent surgery for papillary thyroid cancer. Of these individuals, 43,227 (82.9%) underwent total thyroidectomy, and 8,946 (17.1%) underwent lobectomy.[9][Level of evidence C1]

For patients with papillary thyroid cancer tumors that measured 1 cm or larger, total thyroidectomy resulted in lower recurrence rates and improved survival compared with lobectomy.

In a pattern-of-care study that used the NCDB registry from 1985 to 2003, 57,243 patients with papillary thyroid cancer whose tumors measured 1 cm or larger underwent total thyroidectomy or lobectomy. Trends in the extent of surgery were examined for patients with papillary thyroid cancer over two decades. Logistic regression was used to identify factors that predicted the use of total thyroidectomy compared with lobectomy.[10][Level of evidence C1]

Source links and citations

In a pattern-of-care study that used the NCDB registry from 1985 to 2003, 57,243 patients with papillary thyroid cancer whose tumors measured 1 cm or larger underwent total thyroidectomy or lobectomy. Trends in the extent of surgery were examined for patients with papillary thyroid cancer over two decades. Logistic regression was used to identify factors that predicted the use of total thyroidectomy compared with lobectomy.[10][Level of evidence C1]

Use of total thyroidectomy increased from 70.8% in 1985 to 90.4% in 2003 (P < .0001).

In a pattern-of-care study that used the NCDB registry from 1985 to 2003, 57,243 patients with papillary thyroid cancer whose tumors measured 1 cm or larger underwent total thyroidectomy or lobectomy. Trends in the extent of surgery were examined for patients with papillary thyroid cancer over two decades. Logistic regression was used to identify factors that predicted the use of total thyroidectomy compared with lobectomy.[10][Level of evidence C1]

Patients treated at high-volume medical facilities or academic centers were more likely to undergo total thyroidectomy than were patients examined at low-volume medical facilities or community hospitals (P < .0001).

Publication references

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Preserved source evidence · Not medical advice