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HEALTH PROFESSIONAL · SOURCE READING

Treatment Options for Stage I Gastric Cancer

Source: Gastric Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: February 21, 2025 · Captured 2026-09-09.

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Context: Treatment of Stage I Gastric Cancer

Treatment options for stage I gastric cancer include:

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Surgical resection with one of the following procedures:Regional lymphadenectomy is recommended with all of the above procedures. Splenectomy is not routinely performed.[1]

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Surgical resection with one of the following procedures:Regional lymphadenectomy is recommended with all of the above procedures. Splenectomy is not routinely performed.[1]

Distal subtotal gastrectomy (if the lesion is not in the fundus or at the cardioesophageal junction).

Surgical resection with one of the following procedures:Regional lymphadenectomy is recommended with all of the above procedures. Splenectomy is not routinely performed.[1]

Proximal subtotal gastrectomy or total gastrectomy, both with distal esophagectomy (if the lesion involves the cardia). These tumors often involve the submucosal lymphatics of the esophagus.

Surgical resection with one of the following procedures:Regional lymphadenectomy is recommended with all of the above procedures. Splenectomy is not routinely performed.[1]

Total gastrectomy (if the tumor involves the stomach diffusely or arises in the body of the stomach and extends to within 6 cm of the cardia or distal antrum).

Endoscopic mucosal resection (EMR) for select patients with stage IA gastric cancer.

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Postoperative chemoradiation therapy or perioperative chemotherapy for patients with node-positive (T1 N1) and muscle-invasive (T2 N0) disease.[2,3]

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Neoadjuvant chemoradiation (under clinical evaluation).[4]

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Preserved source evidence · Not medical advice