HEALTH PROFESSIONAL · SOURCE READING
Treatment of Recurrent Small Intestine Cancer
Source: Small Intestine Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: March 6, 2025 · Captured 2026-09-09.
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Treatment options:
For metastatic adenocarcinoma or leiomyosarcoma:
For metastatic adenocarcinoma or leiomyosarcoma:
No standard effective chemotherapy exists for patients with recurrent metastatic adenocarcinoma or leiomyosarcoma of the small intestine. These patients should consider enrolling in phase I or II clinical trials evaluating new anticancer drugs or biological therapy.
For locally recurrent disease:
For locally recurrent disease:
Surgery.
For locally recurrent disease:
Palliative radiation therapy.
For locally recurrent disease:
Palliative chemotherapy.
For locally recurrent disease:
Clinical trials evaluating ways of improving local control, such as the use of radiation therapy with radiosensitizers with or without systemic chemotherapy.
Preserved source evidence · Not medical advice
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