Localized Disease

Source: Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: May 9, 2025 · Captured 2026-09-09.

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Context: Treatment Option Overview for Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)

If technically and medically feasible, primary management of endocrine tumors of the pancreas involves surgical resection with curative intent. Given the rare nature of these tumors, surgical approaches are based on case series and expert opinion rather than randomized controlled trials.[1] The surgical options listed below are based on retrospective series from single reporting centers.[2-4][Level of evidence C2]

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Adjuvant therapy has no proven benefit and is, therefore, investigational. There have been no well-controlled trials of adjuvant therapy after complete tumor resection.[5]

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Preserved source evidence · Not medical advice