TriangleHEALTH PROFESSIONAL · SOURCE READING
Treatment of Stage IV Penile Cancer
Source: Penile Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 7, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.
Stage IV penile cancer is defined by the following TNM classifications:[1]
Source links and citations
T4, Any N, M0
Any T, N3, M0
Any T, Any N, M1
No standard treatment exists that is curative for patients with stage IV penile cancer. Therapy is directed at palliation, which may be achieved either with surgery or radiation therapy.
Treatment options:
Palliative surgery may be considered for control of the local penile lesion and even for the prevention of the necrosis, infection, and hemorrhage that can result from neglected regional adenopathy.
Radiation therapy may be palliative for the primary tumor, regional adenopathy, and bone metastases.
Clinical trials combining chemotherapy with palliative methods of local control are appropriate. Tested chemotherapeutic drugs with some efficacy include vincristine, cisplatin, methotrexate, and bleomycin. The combination of vincristine, bleomycin, and methotrexate has been effective both as adjuvant and neoadjuvant therapy.[2]
Source links and citations
Publication references
Read the original reference and check its publication notices.
Preserved source evidence · Not medical advice