TriangleHEALTH PROFESSIONAL · SOURCE READING
Treatment Overview
Source: Penile Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 7, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.
When diagnosed early (stage 0, stage I, and stage II), penile cancer is highly curable. Curability decreases sharply for stage III and stage IV disease. Because of the rarity of this cancer in the United States, clinical trials specifically for penile cancer are infrequent. Patients with stage III and stage IV cancer are candidates for phase I and phase II clinical trials testing new drugs, biological therapy, or surgical techniques to improve local control and distant metastases.
The selection of treatment depends on the following tumor characteristics:[10,11]
Size.
Location.
Invasiveness.
Stage.
Continue within this section
Preserved source evidence · Not medical advice