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Treatment Options for Resectable or Borderline Resectable Pancreatic Cancer
Source: Pancreatic Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: February 12, 2025 · Captured 2026-09-09.
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Context: Treatment of Resectable or Borderline Resectable Pancreatic Cancer
Treatment options for resectable or borderline resectable pancreatic cancer include:
Neoadjuvant therapy: Neoadjuvant chemotherapy with or without chemoradiation therapy.
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Surgery: Radical pancreatic resection including:
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Surgery: Radical pancreatic resection including:
Whipple procedure (pancreaticoduodenal resection).
Surgery: Radical pancreatic resection including:
Total pancreatectomy when necessary for adequate margins.
Surgery: Radical pancreatic resection including:
Distal pancreatectomy for tumors of the body and tail of the pancreas.[1,2]
Postoperative chemotherapy: Radical pancreatic resection followed by chemotherapy.[3]
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Postoperative chemoradiation therapy: Radical pancreatic resection followed by fluorouracil (5-FU) chemotherapy and radiation therapy.[4-8]
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Preoperative chemotherapy and/or radiation therapy (under clinical evaluation).
Alternative radiation techniques (under clinical evaluation).
Palliative therapies can be considered in patients with any stage of disease. For more information, see the Palliative Therapy section.
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Preserved source evidence · Not medical advice