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Other consolidation and/or maintenance therapy trials
Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 14, 2025 · Captured 2026-09-09.
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Phase III trials of consolidation and/or maintenance therapy have been carried out with cytotoxic drugs, small molecules,[61] vaccines,[62] and radioimmunoconjugates [63] with negative results. Extending the duration of paclitaxel has resulted in modest lengthening of PFS in randomized trials,[64,65] but this process was not adopted as a standard treatment after a subsequent trial.
Evidence (other consolidation and/or maintenance therapy):
The JAVELIN OVARIAN 100 study (NCT02718417) was the first published randomized trial of a checkpoint inhibitor (avelumab, an anti–programmed death-ligand 1 [PD-L1] antibody) in patients with previously untreated epithelial ovarian, fallopian tube, or peritoneal cancer.[66] Between May 2016 and January 2018, 998 patients were randomly assigned to receive either chemotherapy plus avelumab induction followed by avelumab maintenance (n = 331); chemotherapy followed by avelumab maintenance (n = 332); or chemotherapy followed by observation (n = 335).
Source links and citations
The JAVELIN OVARIAN 100 study (NCT02718417) was the first published randomized trial of a checkpoint inhibitor (avelumab, an anti–programmed death-ligand 1 [PD-L1] antibody) in patients with previously untreated epithelial ovarian, fallopian tube, or peritoneal cancer.[66] Between May 2016 and January 2018, 998 patients were randomly assigned to receive either chemotherapy plus avelumab induction followed by avelumab maintenance (n = 331); chemotherapy followed by avelumab maintenance (n = 332); or chemotherapy followed by observation (n = 335).
The study was terminated at interim analysis for futility of reaching the primary end point of improved PFS.
The JAVELIN OVARIAN 100 study (NCT02718417) was the first published randomized trial of a checkpoint inhibitor (avelumab, an anti–programmed death-ligand 1 [PD-L1] antibody) in patients with previously untreated epithelial ovarian, fallopian tube, or peritoneal cancer.[66] Between May 2016 and January 2018, 998 patients were randomly assigned to receive either chemotherapy plus avelumab induction followed by avelumab maintenance (n = 331); chemotherapy followed by avelumab maintenance (n = 332); or chemotherapy followed by observation (n = 335).
More patients in the avelumab arms discontinued study treatment and experienced grade 3 to 5 serious adverse events than patients in the chemotherapy-alone arm.
IMagyn050 (NCT03038100) was a multicenter, placebo-controlled, double-blind, randomized phase III trial of platinum-based chemotherapy and bevacizumab with or without atezolizumab, an anti–PD-L1 antibody. The study reported negative results in the first-line arms for patients who received atezolizumab.[67]
Studies cited in this source section
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